RESUMEN
To assess the effectiveness of sodium hyaluronate Eye Gel in Dry Eye Disease [DED] patients. A Multi-center, Open-label, Uncontrolled clinical trial was conducted in different centers of Pakistan. Ten ophthalmologists conducted this study in which 250 diagnosed patients with dry eye disease were enrolled after obtaining a written informed consent. Ten patients were dropped out during the study period. All patients were assessed as per following criteria for enrolling a patient into the study: Tear Film Break - up time [TBUT] = 10 seconds, Schirmer Test - 1 = 6 mm / 5 minutes and Positive Corneal Staining. Tolerability/safety was assessed by the monitoring and recording of all adverse events. The physical examination was done at baseline, 4[th] week and 8[th] week. The mean age of the patients was 43.4 +/- 17.8 years and out of 240 patients 117 [48.7%] were males and 123 [51.3%] females. The Mean duration of symptoms was 19.3 +/- 23.9. At the initial visit the foreign body sensation was 50.6%, itching 35.9%, burning 50.6%, watering 42.9%, photophobia 25.3% and feeling of dryness in 14.7% of patients. After 4 weeks [2[nd] visit], the symptoms were decreased to 47.1% foreign body sensation, 32.4% itching, 48.2% burning, 41.8% watering, 25.3% photophobia and 13.5% feeling of dryness. At the 3[rd] visit [after 8 weeks] the frequency of symptoms were: 45.3% foreign body sensation, 30.6% itching, 45.9% burning, 40% watering, 24.7% photophobia and 13.5% feeling of dryness. Sodium Hyaluronate can provide a suitable alternate in the treatment of dry eye disease due to its reported efficacy on foreign body sensation, itching, burning, watering, photophobia and feeling of dryness
Asunto(s)
Humanos , Femenino , Masculino , Ácido Hialurónico , Ácido Hialurónico/administración & dosificación , Oftalmopatías/terapia , Geles , FluoresceínaRESUMEN
Forty cases of ocular trauma in children were reviewed. The age of the patients ranged from 2 years to 12 years with a mean of 8 years and 6 months. 32 cases. [80%] needed surgical management and 8 cases 120%] were managed conservatively. Patients of penetrating ocular injuries [Group 1] had poor visual prognosis 6/18 or worse, as compared to blunt ocular trauma [Group 2] and ocular burns [Group 3] 6/6-6/18. Injuries involving the lens in the anterior segment or the posterior segment were associated with afar worse prognosis due to the problems of maintenance of binocular single vision. Children under 6 years had poor visual prognosis due to development of amblyopia. Education of the parents for adopting preventive measures at home and at the place of play would save these children as well as other children from ocular injuries in future