RESUMEN
The anti-ulcer effect of the aqueous extract of Matricaria chamomilla flowers [chamomile extract, CE] had been tested on stress- ethanol induced gastric ulceration in rabbits. The first part of the study was to induce acute gastric ulceration by stress or stress ethanol combinations. Stress alone teas unable to produce gastric ulcerations while ulcer was induced in the group of rabbits exposed to stress in the presence of ethanol [5ml / kg] with a mean value of ulcer index of 108.3mm +/- 29 [n=8]. Histopathological examination was done to confirm the effect of stress-ethanol combination on gastric mucosa. The second part of the study was performed to investigate the pharmacological effect of various concentrations of the aqueous extract of chamomile [1%, 4% and 8%] on gastric ulceration. The extract was given 15 minutes before ethanol administration. The results have shown a significant anti ulcer effect of chamomile extract with mean values of ulcer index of 76. 4mm +/- 14.2 [P< 0.01]; 11mm +/- 14.2 [P<0.005] and 53mm +/- 27.9 [P<0.01] for the concentrations 1%, 4% and 8% respectively as compared to the control value of 133.25 mm +/- 46.2 [n=8]. It is concluded that the extract of Matricaria chamomilla flowers has anti ulcer effect
RESUMEN
Acute lymphoblastic leukaemia [ALL] has long been recognized to be clinically and morphologically heterogeneous .We tried to study, analyze, and interpret the relationships between age, sex, clinical manifestations, FAB classification, and hematological investigations. Over a period of 6 months, sixty-four, newly diagnosed [Sudan Black B 'negative], cases had been included in this study, from different centers. Clinical study was conducted concentrating on the presence of fever, pallor, bleeding tendency, lymph node enlargement, spleen and liver enlargement, neurological and testicular manifestations, and the presence of mediastinal mass on chest x-rays. Hematological investigations included haemoglobin concentration, initial total white cell count, and platelets count. Bone marrow smears were stained with MGG stain and the FAB classification and the FAB scoring system had been used. Showed that children were 61% of total cases while adults were 39%, with the highest age incidence between 0-5 years. Male: female ratio was 2:1. Age incidence in males was higher than that for females for all age groups. Lymph node enlargement and hepatomegaly were the most common clinical findings. The presence of mediastinal mass on chest x-ray was more in male than female sex [39.5% Vs 9.5%]. L2- morphological subtype was more common in both children and adults 87.2% and 92% respectively] than L1 morphological subtype [12.8% and 8% respectively]. No L3 type had been found in our study. ALL is a disease of children mainly with higher incidence in males than females and, unlike the internationally reported cases where L1 type is more prevalent, L2 type is more prevalent in Iraqi cases