Protection against paracetamol-induced hepatotoxicity by acetyl salicylic acid in rats

Acetyl salicylic acid [ASA] given simultaneously with paracetamol decreased paracetamol-induced hepatotoxicity as measured by serum transaminase activities as well as histopathological examination of the liver, without any effect on glutathione depletion. Delayed treatment with [ASA] also reduced paracetamol-induced liver toxicity

Influence of gonadectomy on total body weights gains, fasting blood sugar and certain inorganic serum constituents in normal female rats

Bilateral oophorectomy in adult female rats caused significant enhancement in their body weight gains along with concomitantly profound derangements in the complex homeostatic control mechanisms maintaining normal [fasting blood sugar] and total serum calcium concentration as reflected. These alterations were partly due to the lack of endogenous ovarian oestrogen production created by gonadal ablation and partly mediated indirectly via oestrogen interations with other glandular endocrine secretions. Serum Na[+] and K[+] electrolyte levels were negligibly influenced by surgical castration