Synthesis of thienopyrimidotriazines, a new fused heterocyclic ring system

Benzothieno [2, 3: 4', 5'] pyrimido [2, l-c] [1, 2, 4] triazines 2, 4 and 6 which represent a new fused heterocyclic ring system were synthesized by reacting 2-hydrazino-5, 6, 7, 8-tertrahydrobenzothieno [2, 3-d]-pyrimidin-4 [3H]-one [1] with phenacyl bromide, bromomalononitrile or chloroacetyl chloride, respectively. Condensation of 6 with aromatic aldehydes produced arylmethylene derivatives 7a, b. Reaction of 1 with phthalic anhydride afforded the phthalazine derivative 8. Also, compound 1 reacted with beta- diketones and with ethyl acetoacetate to produce the pyrazolyl 9a-c and pyrazolinone derivatives 11, respectively. Compound 11 condensed with aromatic aldehydes and coupled with diazotized aromatic amines to afford the corresponding arylmethylene and arylazo derivatives 12 and 13, respectively. All compounds were confirmed by IR, HNMR and analytical data

Antimetabolites: a novel synthesis of nonclassical condensed carbocyclic purine analogues

A novel synthesis of condensed carbocyclic purine analogues via reaction of amino-diazoles and amino-triazoles with sodium salts of 2-[hydroxyl-methylene]-1-cycloalkanones was reported and the synthetic potential of the method was demonstrated in this work. The results of the study were given and discussed