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1.
Chinese Journal of Surgery ; (12): 1428-1431, 2007.
Artículo en Chino | WPRIM | ID: wpr-338140

RESUMEN

<p><b>OBJECTIVE</b>To observe the curative effects of bone marrow stem cell (BMSC) and peripheral blood stem cell (PBSC) transplantations on the avascular necrosis of femoral head (ANFH).</p><p><b>METHODS</b>Totally 122 ANFH patients (211 coxae) treated by BMSC or PBSC transplantations were enrolled from July 2004 to December 2006. All of them were classed to different stages according to the ARCO. Control group were desired as themselves before and after treatment. The puncture of femoral artery was conducted with digital subtraction angiography (DSA), and the tubes were inserted into medial femoral circumflex artery, lateral femoral circumflex artery and obturator artery with the cell suspensions were gradually poured into the arteries.</p><p><b>RESULTS</b>The joint pain, joint functions and walking distance of 122 patients were detected for the follow-up. Compared with before treatment, the calibers thickened; vessels increased and blood velocity quickened of femoral head blood-supply artery were observed in 15 patients after 6 months checked by DSA. The reduced areas of femoral head necrosis in 8 patients indicated the new bone formation between 12 and 24 months.</p><p><b>CONCLUSIONS</b>Autologous BMSC and PBSC transplantation results in the new bone formation and improvement of ischemia in areas of femoral head necrosis at 6 months. The change of angiography was observed about 12 to 24 months after cell transplantation. The stem cell transplantation is convenient, safe and effective in the treatment of the ANFH with no adverse reaction, and can be considered as a new therapy of ANFH.</p>


Asunto(s)
Humanos , Trasplante de Médula Ósea , Cabeza Femoral , Patología , Cirugía General , Necrosis de la Cabeza Femoral , Cirugía General , Estudios de Seguimiento , Isquemia , Cirugía General , Trasplante de Células Madre de Sangre Periférica , Trasplante de Células Madre , Métodos , Trasplante Autólogo , Resultado del Tratamiento
2.
Journal of Experimental Hematology ; (6): 557-560, 2002.
Artículo en Chino | WPRIM | ID: wpr-337674

RESUMEN

The purpose of this study is to explore the clinical significance of RBC blood group serological test in nonmyeloablative allogeneic peripheral blood stem cell transplantation (NAPBSCT) of ABO group incompatibility in 4 patients with acute leukemia. ABO and MN blood group of donors and recipients were determined by hemagglutination test and Rh blood group by Diana Gel phenotype Rh card. The changes of blood group in recipients were observed and implant of donor cells was monitored by short tandem repeat-PCR method. The results showed that in 2 cases of 4 recipients the marrow cells appeared mixed chimera of donor and recipient cells, and blood group changed to donor type in 1 of the 2 cases on 100 days after transplantation. In another 2 cases, the marrow cells appeared mixed chimera without blood group chimera on 154 days after transplantation, and rejection of the transplant occurred in 1 of the 2 cases. The determination of hemagglutinin titer showed that the implant rate of donor cells was lower in the recipients with higher hemagglutinin titer and blood group chimera did not appear, conversely, the implant rate was higher in the recipients with lower titer and blood group chimera appeared early. It is concluded that examination of RBC blood group in NAPB SCT can indirectly reflect effectiveness of transplantation, contribute to decide the intensity of conditioning protocol and immunosuppressive therapy after transplantation, estimate prognosis and guide blood transfusion during transplantation.


Asunto(s)
Adulto , Femenino , Humanos , Persona de Mediana Edad , Antígenos de Grupos Sanguíneos , Transfusión Sanguínea , Leucemia Mieloide Aguda , Sangre , Terapéutica , Trasplante de Células Madre de Sangre Periférica , Leucemia-Linfoma Linfoblástico de Células Precursoras , Sangre , Terapéutica , Trasplante Homólogo
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