RESUMEN
Although the novels anti psychotic's drugs are usually grouped together as a category, they are significantly different in many aspects. One is there side effect property. In there affinity to cause, EPS, and Tardive Dyskinesia - the data are still out, although, Clozapine and Quetiapine will cause less TD as compared to Risperidone and Olanzapine. The diabetes mellitus and the weight gain, is an important issue with the atypical anti-psychotics, particularly with Olanzapine and Clozapine. In Japan, the government has issued a warning stating that, Olanzapine is contraindicated in patients with pre-existing diabetes. Patients should be informed of the risk of diabetes with Olanzapine and their blood glucose should be monitored. On 05/03/02, the authorities in the UK have initiated a review of diabetes with Olanzapine because of 40 cases of diabetes four were of diabetic acidosis and one death. The QTc prolongation story, however, in some opinions, is a marketing gimmick then the actually data supports the likelihood of QTc prolongation with Ziprasidone