Predictors of parental behavioral intentions for vaccinating their children against COVID-19 as determined by the modified theory of planned behavior / 한국간호교육학회지

Purpose@#This study attempted to present a strategy to increase behavioral vaccination intention by identifying factors affecting parents’ intention to have their children vaccinated against coronavirus disease 2019 (COVID-19) by applying the modified theory of planned behavior. @*Methods@#An online survey was conducted with 146 parents of children aged 5 to 17 from August 1 to 30, 2022, and, as a result, 146 data were analyzed. The moderating effect of perceived behavioral control in the relationship between parents’ attitude, subjective norms, and behavioral intention for children’s COVID-19 vaccination was analyzed using the Process Macro (10,000 bootstrapping, 95% confidence interval), and a simple slope analysis was performed to identify differences by group. @*Results@#The moderating effect of perceived behavioral control was statistically significant in the relationship between parent’s attitude and subjective norms for COVID-19 vaccination and behavioral intention. In the simple slope analysis, the reinforcement effect was greatest when the level of perceived behavioral control was high. @*Conclusion@#Since vaccination is most likely when recommended by healthcare providers, it is necessary to ensure that health education through community health experts or mass media can be effectively conducted. In particular, objective information on the effectiveness and safety of COVID-19 vaccinations for children, including monitoring of potential side-effects, should be actively reported.

A Study on Bleeding after Shortening the Bed Rest Time of Pediatric Hemato-oncologic Patients after Bone Marrow Examination / 임상간호연구

Purpose@#The purpose of our study was to identify the bleeding risk factors and to validate the safety of shortening the bed rest time after bone marrow examination in pediatric hemato-oncologic patients. @*Methods@#From July 2019 to September 2020, 145 patients were enrolled from a single center. Medical records were reviewed retrospectively. Descriptive statistics were presented, and the data were analyzed using x2 -test, Fisher’s exact test, and a logistic regression. @*Results@#After two hours of bed rest, most of the patients (91.7%) did not have bleeding complications, and only 8.3% of the patients had a minor bleeding. The rate of major bleeding complications, including hematoma, retroperitoneal hemorrhage rate was zero. The bleeding complications was frequently found on bilateral procedures than unilateral procedures and the difference were statistically significant (p<.05). @*Conclusion@#Two hours of bed rest time after bone marrow examination could be safe and adequate in pediatric hemato-oncologic patients.

A Study on Bleeding after Shortening the Bed Rest Time of Pediatric Hemato-oncologic Patients after Bone Marrow Examination / 임상간호연구

Purpose@#The purpose of our study was to identify the bleeding risk factors and to validate the safety of shortening the bed rest time after bone marrow examination in pediatric hemato-oncologic patients. @*Methods@#From July 2019 to September 2020, 145 patients were enrolled from a single center. Medical records were reviewed retrospectively. Descriptive statistics were presented, and the data were analyzed using x2 -test, Fisher’s exact test, and a logistic regression. @*Results@#After two hours of bed rest, most of the patients (91.7%) did not have bleeding complications, and only 8.3% of the patients had a minor bleeding. The rate of major bleeding complications, including hematoma, retroperitoneal hemorrhage rate was zero. The bleeding complications was frequently found on bilateral procedures than unilateral procedures and the difference were statistically significant (p<.05). @*Conclusion@#Two hours of bed rest time after bone marrow examination could be safe and adequate in pediatric hemato-oncologic patients.

Analysis of Patient Safety Incident in Korea / 간호행정학회지

Purpose@#The purpose of this study was to analyze factors related to patient safety incidents by analyzing '2018 patient safety report data' for Korea, and to prepare a plan for preventing patient safety incidents. @*Methods@#Analysis was done for 2018 patient safety report data’published in 2019. In 2018, 9,250 patient safety incidents were reported, and for this study data (3,757) from hospitals with more than 500 beds were analyzed. SPSS 25.0 was used for the crosstabulation analysis and multinominal logistic regression. @*Results@#There were no factors affecting the sentinel event. The main factors of adverse events were age, patient room, treatment room, day duty of nurses, falls, transfusions, and medication. @*Conclusion@#In order to prevent patient safety incidents, elderly patients should receive verbal and nonverbal communication that will help them understand the complexity of the disease. Finding ways to reduce nurse overtime and reduce human error by computerizing patient monitoring systems, fall prevention activities, and patient safety regulations and procedures are necessary.

Novice and Advanced Beginner Nurses’ Patient Safety Management Activities: Mediating Effects of Informal Learning / 간호행정학회지

Purpose@#The purpose of this study is to identify the effects of the organizational factors and nursing competency of novice and advanced beginner nurses on patient safety management activities, and to confirm the mediating effect of informal learning. @*Methods@#Responses to questionnaires from 169 novice and advanced beginner nurses in South Korea were analyzed. For model fit and hypothesis, maximum likelihood method and covariance structure modeling were used, and bootstrapping was used for significance level. Organizational factors and nursing competencies were independent variables. Informal learning and patient safety management activities were mediator and dependent variables, respectively. @*Results@#Informal learning exhibited a partial mediating effect on the relationship between nursing competency and patient safety management activities and completely mediated the relationship between organizational factors and patient safety management activities. @*Conclusion@#In order to improve the patient safety management activities of novice and advanced nurses, there is a need for interventions that can improve organizational changes and individual nursing competency. Based on this, it will be possible to increase patient safety management activities by developing educational programs including informal learning and improving patient safety culture.

Novice and Advanced Beginner Nurses’ Patient Safety Management Activities: Mediating Effects of Informal Learning / 간호행정학회지

Purpose@#The purpose of this study is to identify the effects of the organizational factors and nursing competency of novice and advanced beginner nurses on patient safety management activities, and to confirm the mediating effect of informal learning. @*Methods@#Responses to questionnaires from 169 novice and advanced beginner nurses in South Korea were analyzed. For model fit and hypothesis, maximum likelihood method and covariance structure modeling were used, and bootstrapping was used for significance level. Organizational factors and nursing competencies were independent variables. Informal learning and patient safety management activities were mediator and dependent variables, respectively. @*Results@#Informal learning exhibited a partial mediating effect on the relationship between nursing competency and patient safety management activities and completely mediated the relationship between organizational factors and patient safety management activities. @*Conclusion@#In order to improve the patient safety management activities of novice and advanced nurses, there is a need for interventions that can improve organizational changes and individual nursing competency. Based on this, it will be possible to increase patient safety management activities by developing educational programs including informal learning and improving patient safety culture.

Patient Safety Management Activities of Clinical Nurse: A Modified Theory of Planned Behavior / 간호행정학회지

PURPOSE: The purpose of this study was to develop a structural model for patient safety management activities and to identify the influencing factors of organizational and individual dimensions that promote patient safety management activities and to suggest effective intervention plans.METHODS: A structured self-report questionnaire was used to measure organizational factor, attitude, subjective norm, perceived behavior control, and patient safety management activities. The questionnaires were distributed to 300 nurses and 275 were included in the analysis. SPSS 25.0 and AMOS 21.0 were used to analyze the model fitness, indirect effect, and direct effect of the model.RESULTS: The hypothetical model for patient safety management activities was appropriate. Among the 8 pathways, 6 direct pathways were significant. Organizational factor affected individual attitudes, subjective norms, and perceived behavior control. Perceived behavior control, and subjective norm affected behavioral intention. Behavioral intention affected patient safety management activities. Perceived behavior control did not affect patient safety management activities.CONCLUSION: Organizations and individuals must change together to promote patient safety management activities. The organization should establish practical education and training, systems and regulations. Individuals should increase behavioral intention by strengthening perceived behavioral control and subjective norm.

Mediating Effect of Self-efficacy in the Relationship between Informal Learning, Shared Leadership and Organizational Socialization of Beginner · Advanced Beginner Nurses / 간호행정학회지

PURPOSE: The study was done to investigate the mediating effect of self-efficacy on the relationships between informal learning and organizational socialization and between shared leadership and organizational socialization among short career nurses. METHODS: A structured self-report questionnaire was used to measure organizational socialization, informal learning, shared leadership and self-efficacy. During February, 2017, data were collected from 136 nurses working in hospitals of more than 500 beds. Data were analyzed using hierarchial multiple linear regression with the SPSS/WIN 22.0 program. RESULTS: Informal learning, shared leadership and self-efficacy were positively correlated with organizational socialization of participants and self-efficacy was positively correlated with informal learning and shared leadership of participants. Also, self-efficacy had a partial mediating effect on the relationship between informal learning, shared leadership and organizational socialization. CONCLUSION: The findings indicate that organizational culture with high level of informal learning and shared leadership is an important factor for organizational socialization of short career nurses. It is also expected that self-efficacy can further promote their organizational socialization.

Factors Influencing Field Adaptation in Newly Graduated Nurses / 정신간호학회지

PURPOSE: The purposes of this study were to investigate the effects of workplace bullying and positive psychological capital on field adaptation in newly graduated nurses. METHODS: The participants in this study were 132 nurses from three tertiary hospitals who had less than 12 months of nursing experience. From March 28 to May 15, 2016, data were collected using a structured questionnaire and analyzed using SPSS/WIN 22.0. RESULTS: The mean score for field adaptation of participants was 2.98±0.39, for workplace bullying, 1.61±0.66, and for positive psychological capital, 3.67±0.54. Sub domains of workplace bullying showed a negative correlation with field adaptation (r=-.21~-.39), and Sub domains of positive psychological capital showed a positive correlation with field adaptation (r=.35~.47). Significant factors that influenced field adaptation were optimism of positive psychological capital and work related bullying of workplace bullying. These factors explained 33.0% of the variance in field adaptation. CONCLUSION: These findings indicate that positive psychological capital at the individual level and workplace bullying at the organizational level should be the focus in the efforts to promote effective field adaptation in newly graduated nurses.

Involvement of ROS in Curcumin-induced Autophagic Cell Death

Many anticancer agents as well as ionizing radiation have been shown to induce autophagy which is originally described as a protein recycling process and recently reported to play a crucial role in various disorders. In HCT116 human colon cancer cells, we found that curcumin, a polyphenolic phytochemical extracted from the plant Curcuma longa, markedly induced the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II and degradation of sequestome-1 (SQSTM1) which is a marker of autophagosome degradation. Moreover, we found that curcumin caused GFP-LC3 formation puncta, a marker of autophagosome, and decrease of GFP-LC3 and SQSTM1 protein level in GFP-LC3 expressing HCT116 cells. It was further confirmed that treatment of cells with hydrogen peroxide induced increase of LC3 conversion and decrease of GFP-LC3 and SQSTM1 levels, but these changes by curcumin were almost completely blocked in the presence of antioxidant, N-acetylcystein (NAC), indicating that curcumin leads to reactive oxygen species (ROS) production, which results in autophagosome development and autolysosomal degradation. In parallel with NAC, SQSTM1 degradation was also diminished by bafilomycin A, a potent inhibitor of autophagosome-lysosome fusion, and cell viability assay was further confirmed that cucurmin-induced cell death was partially blocked by bafilomycin A as well as NAC. We also observed that NAC abolished curcumin-induced activation of extracelluar signal-regulated kinases (ERK) 1/2 and p38 mitogen-activated protein kinases (MAPK), but not Jun N-terminal kinase (JNK). However, the activation of ERK1/2 and p38 MAPK seemed to have no effect on the curcumin-induced autophagy, since both the conversion of LC3 protein and SQSTM1 degradation by curcumin was not changed in the presence of NAC. Taken together, our data suggest that curcumin induced ROS production, which resulted in autophagic activation and concomitant cell death in HCT116 human colon cancer cell. However, ROS-dependent activation of ERK1/2 and p38 MAPK, but not JNK, might not be involved in the curcumin-induced autophagy.