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Objective To investigate the effect of racecadotril granules combined with montmorillonite on infantile rotavirus enteritis and myocardium enzymogram.Methods Retrospective a total of 275 infants and young children with rotavirus enteritis treated in Seventh Hospital of Ningbo from September 2014 to January 2016,were divided into the control group and the combined treatment group according to the treatment method.The combined treatment group were treated with montmorillonite powder and racecadotril granules, the control group were treated with montmorillonite powder.The negative rate of stool were observed three days after treatment,compared the symptom relief time,the level of inflammatory cytokines and myocardial enzyme spectrum between two groups before and after treatment .Results The stool negative rate of combined treatment group ( 79.31%) higher than the control group(67.69%) after three days of treatment;the levels of IL-18,IL-6 and hs-CRP in the combined treatment group were lower than those in the control group(P<0.05);the antiemetic time,dehydration correction time and recovery time of stool were shorter in combination therapy group than those in control group(P<0.05);there was no difference in the levels of myocardial enzyme between the two groups before treatment.The level of CK-MB,LDH,CK and AST in the two groups after treatment were lower than before treatment,and the level of CK and CK-MB in the combined treatment group was lower than the control group ( P<0.05 ) .Conclusion Racecadotril granules combined with montmorillonite powder has a good therapeutic effect on infantile rotavirus enteritis can significantly improve clinical symptoms, reduce the levels of inflammatory cytokines in patients.
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<p><b>OBJECTIVE</b>To evaluate the toxic effects of mixture of volatile organic compounds (VOCs) on Mice Testis related enzymes and hormones.</p><p><b>METHODS</b>After determining the median lethal dose (LD₅₀) of VOCs using the acute toxicity test, 40 male clean inbred Kunming mice were assigned to 1/8 LD₅₀ VOCs exposure group, 1/4 LD₅₀ VOCs exposure group, and 1/2 LD₅₀ VOCs exposure group, as well as positive control group with cyclophosphamide (60 mg/kg) and negative control group with tea oil, with 8 mice in each group. The mice were intraperitoneally injected with respective agents for 5 days. The levels of testis testosterone, estradiol, follicle stimulating hormone, and luteinizing hormone were determined by ELISA. Meanwhile, the activity of testicular marked enzymes such as lactate dehydrogenase, gamma-glutamyl transpeptidase, acid phosphatase, and glucose-6-phosphate dehydrogenase were examined.</p><p><b>RESULTS</b>Compared with the negative control group, the 1/8 LD₅₀ exposure group had a significantly increased testis coefficient (P<0.05). Both the activity of testicular marked enzymes and the levels of testicular sex hormones in all exposure groups showed significant downward trends with increasing VOC doses compared with those in the negative control group (P<0.05).</p><p><b>CONCLUSION</b>VOCs have obvious toxicity to mouse testis by changing the levels of testicular sex hormones and the activity of testicular marked enzymes.</p>