Asunto(s)
Países en Desarrollo , Diagnóstico , Humanos , Patología , Calidad de la Atención de SaludRESUMEN
Kikuchi-Fujimoto lymphadenitis is a distinctive entity which is easily recognised in its classical histology. However, cases which are biopsied in the early stage of the disease, before entering the necrotic phase may be misdiagnosed as non-Hodgkin's lymphoma. Ten cases of Kikuchi-Fujimoto disease which mimicked non-Hodgkin's lymphoma and in which less than 10% of the lymph node was occupied by necrosis were chosen for this study. The patients included 4 males and 6 females with an age range of 15-40 years. Eight patients presented with cervical lymphadenopathy. The pathologic areas ranged from 70% to 95% of the total nodal area. The features that helped distinguish this lesion from non-Hodgkin's lymphoma were: 1) a sprinkling of karyorrhectic debris throughout the node 2) plasmacytoid monocytes as well as "histiocytes" in the company of transformed lymphocytes (immunoblasts) 3) enlarged mottled T-zone areas, and 4) presence of residual lymphoid follicles. Follow up on six patients revealed no evidence of disease.
Asunto(s)
Adolescente , Adulto , Diagnóstico Diferencial , Femenino , Linfadenitis Necrotizante Histiocítica/patología , Humanos , Linfoma no Hodgkin/patología , Masculino , Registros Médicos , Estudios RetrospectivosRESUMEN
Ectopic gastric epithelium is common in the cervical esophagus. However, complications arising from such tissue are rare. We report an adenocarcinoma arising in ectopic gastric mucosa of the cardiac type in the cervical esophagus of a 60-year-old man.
Asunto(s)
Adenocarcinoma/patología , Transformación Celular Neoplásica/patología , Coristoma/patología , Epitelio/patología , Enfermedades del Esófago/patología , Neoplasias Esofágicas/patología , Esófago/patología , Mucosa Gástrica , Humanos , Masculino , Persona de Mediana EdadRESUMEN
A patient of familial adenomatous polyposis (FAP) without extra intestinal lesions is presented. The patient underwent a proctocolectomy with J pouch ileal reservoir with an ileoanal anastomosis. The clinical course was further complicated by an adenocarcinoma developing in the J pouch. This was excised totally and a terminal illeostomy was constructed. The aim of doing a prophylactic proctocolectomy in familial polyposis coli is to prevent a malignancy developing and to restore function with an illeoanal pouch. However polyps can occur in the gastric, duodenal and intestinal mucosa, which can lead to malignancy. Greater awareness and close follow up is needed even after prophylactic proctocolectomy.
Asunto(s)
Adenocarcinoma/etiología , Poliposis Adenomatosa del Colon/cirugía , Femenino , Humanos , Masculino , Proctocolectomía Restauradora/efectos adversosRESUMEN
Interstitial (Leydig) cell tumour of the testis is an extremely uncommon tumour. We report one such tumour displaying histologic features of malignancy--large size capsular invasion and moderate nuclear pleomorphism in an adult male. The tumour also showed crystalloids of Reinke, confirming Leydig cell origin.
Asunto(s)
Núcleo Celular/patología , Humanos , Tumor de Células de Leydig/diagnóstico , Masculino , Persona de Mediana Edad , Neoplasias Testiculares/diagnósticoRESUMEN
A case of low grade hemangiopericytoma of three years duration occurring in the upper end of the femur of a 70 year old man is described. Radiologically, the upper third of the right femur showed a destructive expansile osteolytic lesion with soft tissue extension. The tumour was partially encapsulated. Mitoses were 0-1 per 10 high power fields, suggesting the low grade malignant nature of the lesion. It is felt that all hemangiopericytomas occurring in bone should be considered biologically malignant.
Asunto(s)
Anciano , Desarticulación , Neoplasias Femorales/patología , Fémur/patología , Hemangiopericitoma/patología , Cadera/cirugía , Humanos , Masculino , Cuidados PaliativosRESUMEN
Oral Metastasis from a carcinoma of the urinary Bladder is extremely uncommon. Two cases of transitional cell carcinoma of the Bladder, presenting eighteen and ten months after initial diagnosis, one with soft tissue metastasis in the upper alveolus and the other with bony metastasis to the mandible are discussed.
Asunto(s)
Anciano , Carcinoma de Células Transicionales/patología , Neoplasias Gingivales/secundario , Humanos , Masculino , Neoplasias Mandibulares/secundario , Maxilar/patología , Persona de Mediana Edad , Hueso Paladar/patología , Neoplasias de la Vejiga Urinaria/patologíaRESUMEN
Bleeding time, clot retraction, platelet factor 3 availability and platelet aggregation in response to ADP, epinephrine, collagen and ristocetin were studied in 13 cases of acute leukemia which included 5 cases of acute myeloid leukemia, 2 of chronic myeloid leukemia in blast crisis and 6 of acute lymphoblastic leukemia. More than one abnormality was seen in all the patients. Defects in bleeding time, clot retraction and platelet factor 3 availability were encountered in 43% of cases. Platelet aggregation responses to all the reagents were significantly impaired. There was, however, no consistency in the pattern of the defects.
Asunto(s)
Crisis Blástica/sangre , Plaquetas/fisiología , Humanos , Leucemia Mielógena Crónica BCR-ABL Positiva/sangre , Leucemia Mieloide Aguda/sangre , Agregación Plaquetaria/fisiología , Pruebas de Función Plaquetaria , Leucemia-Linfoma Linfoblástico de Células Precursoras/sangreRESUMEN
Sinus histiocytosis with massive lymphadenopathy involving organs other than the lymph nodes is a rare event. A case of SIIML presenting with multiple skin and subcutaneous nodules and multiple osteolytic lesions is described. A search of the Indian literature revealed many cases of nodal SIIML, but none of the reported cases had prominent extranodal involvement.
Asunto(s)
Niño , Histiocitosis Sinusal/complicaciones , Humanos , Enfermedades Linfáticas/complicaciones , MasculinoRESUMEN
Bleeding time, clot retraction, platelet factor 3 availability and platelet aggregation in response to ADP, epinephrine, collagen and ristocetin were studied in 12 cases of chronic leukemia which included eight of chronic myeloid leukemia, two of chronic lymphatic leukemia and two of CLL related disorders. One or more abnormalities in platelet function were detected in all the cases. Among the cases of CML, bleeding time was prolonged in one, clot retraction was impaired in one and PF3 availability was decreased in one case. Defects in platelet aggregation were variable. Among the cases of CLL and CLL related disorders, bleeding time was prolonged in two, clot retraction was impaired in one and PF3 availability was decreased in three cases. Platelet aggregation responses were significantly impaired in all the cases.