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INTRODUCTION: Regenerative therapies using biomaterials require accurate information on interactions between the implanted material and the human body. To improve the process of bone regeneration it is necessary to obtain a better understanding of the influence of the surfaces on the early stages of osseointegration. This work aims to investigate the dynamic interaction between simulated body fluid (SBF) and titanium surfaces (Ti cp) immediately after their first contact. METHODS: Ti cp samples were passed through physicochemical treatments after immersion in acid solution, alkaline solution and solutions containing TiO2 and Ca2+, to obtain three different surfaces. These were characterized by electron microscopy and free energy estimates. The evaluation of the interaction with SBF was performed by measuring the dynamic contact angles after contacting the surfaces. RESULTS: The effects of SBF wettability were more significant on surfaces according to high energy estimates. A comparative analysis of the three types of surfaces showed that fluid spreading was greater in samples with greater polar components, indicating that the surface nature influences interactions in the early stages of osseointegration. CONCLUSION: The results indicate the influence of polar interactions in the dynamic wettability of the SBF. It is possible that these interactions can also influence cellular viability on surfaces. Based on these results, new experiments are being designed to improve the presented methodology as a tool for the evaluation of biomaterials without the need for in vivo experiments.
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Revestimento bioativo de alta adesão foi obtido por modificações físico-químicas na superfície do titânio para formar estruturas de multicamadas contendo TiO2 e fosfatos de cálcio Ca/P. Medidas de tração foram realizadas para quantificar as forças de interfaces, observadas perto de 10 MPa. A ativação das superfícies foi evidenciada por estimativas de energia livre, cujos efeitos são atribuídos tanto à difusão atômica quanto à polarização da superfície. Os testes mostraram a bioatividade e a qualidade da superfície para a aplicação tecnológica...
This paper reports the development of a high adhesion bioactive coating promoted by increasing titanium free surface energy. Through physical-chemical modifi cations, multilayer structures with titania (TiO2) and calcium phosphates (Ca/P) were formed. Adhesion strength measurements were performed to quantify the interfacial force aspects and results were near 10MPa. Surface activation was evidenced by free energy estimates, with results attributed to the atomic diffusion process. The bioactivity tests showed the quality of this surface for technological applications...