Central neurotoxicity of gentamicin: Gentamicin induced 'in vitro' Mg2+ depedent ATP ase activity in auditory area of rat brain

The exact mechanism of otoneurotoxicity of gentamicin is unknown. A study was carried out on the auditory cortex of rat brain both 'in vitro' and 'in vivo' following the administration of gentamicin 135 mglkg body weight for 21 days. Interestingly, the Mg2+ dependent ATPase was increased following the intoxication of gentamicin