Assessment of antihyperlipidemic properties of aqueous extract of cassia fistula leaves

To study antihyperlipidemic properties of aqueous extract of Cassia fistula leaves in mice. Experimental study. This study was conducted at Pharmacology Laboratory of Islamic International Medical College, Rawalpindi, and National Institute of Health, Islamabad from February to April 2011. 40 male Balb/c mice were used which were randomly divided into 4 groups i.e. Group A, B, C and D, each group containing 10 mice. Duration of study was 8 weeks after acclimatization [1 week]. Group A served as control group [received standard mice diet], Group B as disease control [received 2% cholesterol diet] and Group C and D as Cassia fistula groups [received 2% cholesterol diet + aqueous extract of Cassia fistula leaves 250 and 500 mg/kg respectively]. At the end of 8 weeks, blood samples of all the mice were analyzed. In disease Group B, there was significant rise in the levels of serum total cholesterol, triglycerides and LDL-C and decline in HDL-C. In Group C and D [Cassia fistula groups], there was much less rise in cholesterol, triglycerides and LDL-C especially in Group D. Also, there was significant increase in HDL-C level in group D. The results demonstrate that administration of aqueous extract of Cassia fistula leaves, along with cholesterol diet, not only prevented the rise in serum cholesterol, triglycerides and LDL-C levels but also increased the HDL-C level, demonstrating antihyperlipidemic properties of the extract

Blood band and disaster response services; work up for the work up for the effective management

Assessment and Comparison of blood group typing among male, female urban and rural population of Tehsil Hassan Abdal, District Attock, Punjab, Pakistan. A total of 400 healthy male, female volunteers belonging to both rural and urban areas were tested for blood group typing. In the selected population in case of ABO blood groups A, B and O were pre dominant. In the same population in case of Rh blood groups Rh + was pre dominant. The assessment and comparison of blood groups in various subclasses of selected population can be beneficial in effective management of blood bank, swift management of disasters requiring massive blood transfusions and development of blood donor society

Alcoholic intoxication; is it an exclusively male affair?

To assess the epidemiology of Alcohol consu, Attack, Punjab, Pakistan. The Medico legal cases record from 2009 - 2011 were studied for alcohol cases at Uivil Hospital Hassan Abdal. the selected medico legal cases alcohol consumption was surprisingly reported only in male gender. The involvement of younger males in alcohol consumption was found to be predominant. The trend of alcohol consumption was noted among both urban as well as rural population, with more urban cases as compared to rural

Hepatoprotective effect of garlic [allium sativum] and milk thistle [silymarin] in isoniazid induced hepatotoxicity in rats

Assessment and comparison of hepatoprotective role of garlic and silymarin in antituberculosis drug [Isoniazid] induced hepatotoxicity. Healthy rats weighing 150-200g were selected for the study. Rats were divided into four groups, i.e. group A [Control], group B [INH treated group], group C and D serve as experimental groups. The group A received only the normal diet, Group B along with normal diet received the isoniazid [50 mg/kg/day], Group C along with normal diet received the isoniazid [50 mg/kg/day] and Silymarin [200 mg/kg/day], and Group D along with normal diet received the isoniazid [50 mg/kg/day] and garlic [0.25 g/kg/day]. On completion of 28 days of treatment blood samples were collected for the assessment of liver function. In group B there was abnormal rise in the levels of biochemical markers [ALT, AST, ALP and Total Bilirubin]. In group C the biochemical markers were near normal levels and in group D the levels of biochemical markers were within normal limits. Both the garlic and silymarin have shown the hepatoprotective effect against the Antituberculosis drug [isoniazid] induced hepatotoxicity in experimental animal model