Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Añadir filtros








Intervalo de año
1.
IJI-Iranian Journal of Immunology. 2007; 4 (4): 241-245
en Inglés | IMEMR | ID: emr-165502

RESUMEN

Papillon-Lefevre Syndrome [PLS] is a rare autosomal recessive disorder characterized by diffused palmoplantar keratoderma and severe periodontitis. Increased susceptibility to infections due to impairment of the immune system is considered to be involved in pathoetiology of this disease. According to the crucial function of HLA molecules in immune responses and association between certain HLA class I alleles and some periodontal or skin diseases, this study was designed to evaluate the relation of HLA class I genes and PLS. HLA class I genes were typed by PCR-SSP [Polymerase Chain Reaction with Sequence Specific Primers] method in eight Iranian PLS patients and 89 healthy controls. The results showed no significant difference between the patients and controls. Moreover, identical haplotypes or genotypes were also observed among PLS patients and their healthy siblings. It seems that further genes are involved in genetic susceptibility to PLS. However the results of this study showed no significant association between HLA class I genes and PLS, molecular analyses of killer immunoglobulin-like receptors [KIRs] and MHC class I chain-related gene A and B [MICA/B] in PLS may clear many obscure points about the genetic factors involved in these diseases

SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA