Ameliorative effect of vitamin e on oxidative stress induced by bisphenol a in female albino rats

Objective: Oxidative stress is induced by bisphenol A [BPA] and affects many organs. Vitamin E is an effective antioxidant which prevents the activity of free radicals. This study was aimed to clarify the effect of vitamin E on the oxidative stress induced by chronic administration of BPA

Materials and methods: 30 female albino rats were divided into 3 groups [10/each]; group1: control rats, group 2: rats treated with bisphenol A [20 mg/ kg.B.wt] for three months, and group 3: rats treated with bisphenol A [20 mg/kg.B.wt] for three months, then treated with BPA and vitamin E [0.57/100 g B.wt] for other 15 days

Results: BPA induced hormonal disrupt in liver and kidney dysfunctions and hyperlipidemia. Vitamin E ameliorated all these parameters

Conclusion: since we exposed to many harmful disruptions and oxidative stress compounds, we must take vitamin E as a protective agent

Effect of Bisphenol A on the first generation of female rats from both parents treated with the same Xenoestrogen

Background: Bisphenol A [BPA] is a worldwide used endocrine disruptor that is incorporated in many plastic industries. The exposure of human to such substances starts early during the fetal life, postnatal life and extends throughout the life of the individual. Many agencies raised warnings against the excessive use of such substances. The aim of the present work was to evaluate the extent to which BPA can affect the first generation [of parents treated with the same compound, during pregnancy and lactation], which treated with the same compound during their life time

Materials and Methods: Group 1: 15 control female rats. Group 2: 15 female rats of the first generation treated with BPA [20mg/kg b.wt] for one month. Sexual hormones, liver and kidney functions were measured

Results: BPA induced increase in breast and ovarian tumor markers. It also showed significant increase in estrogen, FSH, prolactin, and progesterone. It is also increased liver function, kidney function, lipid profile. In the same time it leads to decrease in LH, HDL, and protein levels

Conclusion: BPA induced toxicity, which is mediated by oxidative stress. This study ringing the bells of danger for using such compounds

Effect of noise and crowding related stress on serum level of cortisol ACTH, epinephrine and insulin in female albino rats

Noise and crowding are the most stressful factors for human beings.Study aimed to clarify their effect on cortisol, ACTH, epinephrine, insulin and the amelioration effectof Sulpiride. Thirty six female rats were divided into six groups [6/each]:1- Rats served as control, 2- Rats treated with Sulpiride drug, 3- Rats exposed to noise [90db, 3hr. perday] for 45 days. 4- Rats exposed to noise and treated with sulpiride drug, 5- Rats exposed tocrowding. 6- Rats exposed to noise and treated with Sulpiride drug. Noise and crowding stresses caused a significant increase of cortisol, ACTH and epinephrinewhile there was a significant decrease in insulin hormone. Sulpiride drug ameliorated theseparameters. it is useful to use Sulpiride drug with people who are exposing to noise and crowdingstress

Effect of noise and crowding stresses on hypothalamic-pituitary-gonadal axis and protective effect of sulpiride drug in adult female albino rats

Noise and crowding are the most stressful factors which cause depressant effects on human beings, especially females.Therfore this study was aimed at clarifying their effects on hypothalamus pituitary gonadal axis hormones [luteinizing hormone [LH] and follicle-stimulating hormone [FSH], estrogen [E2]and progesterone as well as prolactin [PRL]and the possible protective effect of antidepressant drug;sulpiride. Sixty adult female rats were divided into six groups [10/each]: 1- Rats served as control, 2- Rats treated with sulpiride drug only, 3- Rats exposed to noise [90db, 3hr. per day] for 45 days, 4- Rats exposed to noise and treated with sulpiride drug, 5- Rats exposed to crowding and 6- Rats exposed to crowding and treated with sulpiride drug. Results: Noise and crowding stresses caused a significant decrease of estrogen [E2], progesterone [P], LH and FSH levels and high significant increase in PRL level. Sulpiride drug ameliorated these parameters changes except PRL level which showed a high significant level compared to control group. It is useful to use antidepressant drug [e.g. sulpiride] with people who are exposing to noise and crowding stress

Effect of crowding stress on lung and heart of the adult albino rats and the possible protective role of sulpiride

Exposure to crowding stress is associated with increased respiratory system morbidity, However, the underlying mechanisms are unclear. Thus, there is a need for more study of this harmful effect. Sulpiride had been shown to have a protective role against crowding stress on other systems but this role was not studied well on the respiratory and cardiovascular systems. Investigating the possible harmful effects of crowding on adult albino rats' lung and heart and the possible protective role of combined sulpiride treatment. The present study was carried out on 24 adult albino rats of local strain weighing 120 +/- 3 g which were randomly divided equally into Group 1[C, untreated negative control], Group 2 [Cr, crowding exposed or positive control] where rats were exposed to crowding in a cage [20x20x20 cm- 6 rats /cage] for 1 month, Group 3[D, sulpiride-treated] where the rats were exposed to sulpiride "0.028 mg/B.W./day" and Group 4 [Cr+D, crowding + sulpiride-treated]. Paraffin sections were prepared for histological, histochemical and morphometric studies. The data were statistically analysed. The rats exposed to crowding only or sulpiride only showed highly significant damaging changes on lung such as thickening in the interalveolar septa and obliteration of the alveoli, inflammatory cells infiltration within the pulmonary interstitium, peribronchiolar infiltration and fibrosis, thickening of the pulmonary blood vessels walls, interstitial collagen fibres deposition and apoptotic cellular changes. On the level of heart, significant decrease in the diameters of the myocardial muscle fibres with focal areas of necrosis, apoptotic changes and increased collagen fibres deposition was marked in sulpiride group. When crowding and sulpiride treatments were combined, the damaging effects were maximized on the lung and heart. These results provided evidence that crowding stress causes obvious lung and heart tissue damages. No protective role for sulpiride was proofed. This is because using sulpiride alone or in combination with crowding showed marked damaging effects on the lung and heart tissues

Effect of crowding stress and /or sulpiride treatment on some physiological and histological parameters in female albino rats

Crowding is the most stressful factor on human being. So these studies aimed to clarify effect on some physiological and histological parameters. 36 Female rats were divided into four groups [6/each]:1-control, 2-treated with sulpiride drug,3- crowded exposure 4- crowded + drug. drug recorded a significant increase only in the percentage of body weight gain but the other parameters showed no significant changes. Stress recorded a significant increase in glucose, ALT, GGT, TP, globulin, creatinine, total lipids, TG, cholesterol, HDL-C, LDL-C. A significant decrease in percentage of body weight gain and A/G ratio were also detected. Sulpiride drug ameliorated most of these parameters. Concerning the histological and histochemical studies sulpiride treatment showed no detectable changes in the kidney and liver tissues with exception of increased lymphocytes. Exposure to crowding showed many dystrophic changes in both tissue, but drug treatment improved all the previous changes and this indicates the protective effect of sulpiride against crowding exposure. it is useful to use sulpiride drug in people who exposed to crowded stress