Trapped after Coming Buttocks: A Consequence of Sacrococcygeal Teratoma: A Case Report.

Sacrococcygeal teratoma (SCT) is the commonest fetal tumour but a rare cause of obstructed labour. If undiagnosed during antenatal period, high index of suspicion is required during labour to make a diagnosis. In this case report, we present a case of sacrococcygeal teratoma (SCT) which was diagnosed at the time of delivery. The fetus, with a massive ruptured sacrococcygeal mass, was delivered by traction and suprapubic pressure. Histology report revealed malignant sacrococcygeal teratoma. The diagnosis of sacrococcygeal teratoma (SCT) should form part of the differential diagnoses when there is obstructed labour after the delivery of the fetal shoulders so that appropriate management can be instituted.

Testicular and paratesticular non- neoplastic lesions in university of maiduguri teaching hospital: a 10-year retrospective review

Objectives: The present study is undertaken to describe the spectrum of histopathological features and age distribution of non-neoplastic testicular and paratesticular lesions in the University of Maiduguri Teaching Hospital (UMTH). Materials and methods: A retrospective descriptive study of 70 testicular and paratesticular nonneoplastic lesions was conducted over a period of 10 years; between January-2005 and December2014 in the Department of Histopathology, UMTH. Histopathological examination was done after routine processing and staining with Haematoxylin and Eosin. Special stain (Ziehl-Neelsen stain) was done to confirm the presence of acid fast bacilli in cases of tuberculous epididymoorchitis. Results: There were of which (24.3%) followed by testicular torsion and infarction (14.3%). The youngest patient was 2 years old and the oldest was 80 years of age. The highest incidence occurred in the age range of 30 ­ 59 years with a total of 25 cases representing 35.7%. The lowest incidence was observed in the elderly (= 60 years) with a total of 21 cases (30%). Conclusion: This study shows that inflammatory disorders are the predominant causes of the testicular and paratesticular non-neoplastic lesions capable of interfering with fertility and mimicking malignancy. There is also the need to emphasise the necessity of proper evaluation and treatment of acute orchitis and microabscess to avoid unnecessary orchidectomy.70 cases of non-neoplastic testicular and paratesticular lesions the majority were inflammatory disorders accounting for 53 cases (75.7%). They included acute orchitis (4.3%), tuberculosis (12.9%), schistosomiasis (8.6%), hydrocoele (24.3%), chronic orchitis (10.0%), epididymal cyst (11.4%) and tumoral calcinosis (4.3%). Other categories of the lesions included congenital abnormalities (10.0%) and traumatic disorder (14.3%). Long-standing hydrocoele was the commonest lesion

Effects of the Methanol Root Extract of Cissampelos mucronata A. Rich on the Kidney and Liver of Rats- a Histological and Biochemical Study.

Aim: The aim of this study was to determine the potential toxicologic effects of the methanol root extract of Cissampelos mucronata (A. Rich) on liver and kidney tissues. Methodology: A total of 30 rats were used for the study consisting of 5 female rats for the acute toxicity study and 25 rats for the 28 day repeated toxicity studies, the 25 rats were divided into five groups of 5 rats per group. Group I served as the control, while rats in groups II-IV where administered 100, 200 and 300 mgkg-1 body weight of the extract respectively for 28 days. Rats in group V were administered 300 mgkg-1 of the extract for 28 days and allowed to stay for 14 days post treatment. At the end of the experimental period the rats were sacrificed, kidney and liver weight taken and fixed for routine histological examinations while blood was obtained for biochemical analysis. Results: Acute toxicity studies revealed an LD50 of >2000mgkg-1 following oral administration of the extract while 28 days administration of 100, 200 and 300mgkg-1 of the extract caused a significant decrease in body weight (p<0.01) and significant increases in the serum levels of alanine aminotransferase, alkaline phosphatase, total protein and albumin(P<0.05-0.001). Histopathological assessment of the liver and kidney tissues revealed moderate lymphocytic infiltration and thrombus formation within the central veins in the liver, moderate epithelial sloughing of the proximal convulated tubules in renal tissues with no remarkable recovery following withdrawal of the extract. Conclusion: This study suggests that prolonged and constant use of the extract is both hepatotoxic and nephrotoxic.