Investigation on working conditions and health of employees in some handicraft villages

Cross-sectional study was conducted in 6 handicraft villages, 600 producing households, 1.672 handicraft employees and 135 agricultural employees. The study results showed that: 98.4% of producing households had generated hazardous factors such as noise, heat, dust, micro-organism etc. In food processing village: 83.3% of micro-climate samples and 100% of light samples exceeded the permissible limits. In mechanical villages: 100% of noise sample accessed the permissible limit. In fine arts furniture villages: 91.3% of micro-climate sample, 75% of light sample and 69.5% of dust sample exceeded the permissible limits. In general, almost of handicraft employee had poor knowledge on risk factors at workplaces and their harms. The disease prevalence of handicraft employees was 85.3% that was higher than that of agricultural employee (58,5%). The difference was statistic significant (p=0.0001; RR= 1.46). Handicraft employee liked to have healthcare services at commune’s health station or have health workers at worker place and health insurance.

Effects of isoniazid and pyrazinamide on bioavailability of rifampicin when co-administered rifampicin-isoniazid

The study was conducted to compare bioavailability of rifampicin at the same doses with and without isoniazid and pyrazinamide in the standard separate tablets in 12 healthy volunteers. Bioavailability of rifampicin was estimated by plasma concentration of rifampicin from 0h to 24h after administration. Plasma rifampicin concentration was determined by HPLC method. The results revealed that Cmax and AUC for rifampicin was reduced (31.24% and 25.95%, respectively) when rifampicin - isoniazid - pyrazinamide was administeredat the same time. It was concluded that bioavailability of rifampicin was affected by presence of isoniazid and pyrazinamide.