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Acta cir. bras ; 32(2): 125-139, Feb. 2017. tab, graf
Artículo en Inglés | LILACS | ID: biblio-837679

RESUMEN

Abstract Purpose: To evaluate the effect of human amniotic membrane (hAM) fragment on inflammatory response, proliferation of fibroblast and organization of collagen fibers in injured tendon. Methods: Sixty rats were divided into 3 groups: C - surgical procedures without tendon lesion and with simulation of hAM application; I - surgical procedures, tendon injury and simulation of hAM application; T - surgical procedures, tendon injury and hAM application. These groups were subdivided into four experimental times (3, 7, 14 and 28 days). The samples underwent histological analysis and ATR-FTIR spectroscopy. Results: Histological analysis at 14 days, the T group showed collagen fibers with better alignment. At 28 days, the I group presented the characteristics described for the T group at 14 days, while this group presented aspects of a mature connective tissue. FT-IR analysis showed a clear distinction among the three groups at all experimental times and groups T and I presented more similarities to each other than to group C. Conclusion: Acute injury of tendon treated with human amniotic membrane fragment showed a faster healing process, reduction in inflammatory response, intense proliferation of fibroblasts and organization of collagen fibers.


Asunto(s)
Animales , Masculino , Ratas , Tendón Calcáneo/lesiones , Traumatismos de los Tendones/cirugía , Cicatrización de Heridas , Amnios/trasplante , Rotura/cirugía , Rotura/patología , Tendón Calcáneo/patología , Traumatismos de los Tendones/patología , Factores de Tiempo , Colágeno/fisiología , Ratas Wistar , Espectroscopía Infrarroja por Transformada de Fourier , Modelos Animales
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