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Objective: To observe the effect of LQC on relieving fever in rabbits and the effect on secretion of TNF-?, probe into the correlated mechanism of LQC on pharmacological action and its substance basic of “treating different diseases with the same therapeutic principle”. Method: Rabbit pyrexia model was made by injecting lipopolysacchatide (LPS) into auris edge vein, and alveolar epithelial cell II damnification model was made by adding LPS to culture medium. The change of temperature and TNF-?lever in cell culture supernate were observed before or after using LQC. Result: LQC can resist the temperature rising by LPS, relieve pyrexia reaction, restrain the augment of TNF-?content. Conclusion: The results suggested that LQC possess distinct function of relieving fever, which is likely related to restraining the abnomal augment of TNF-?.
RESUMEN
AIM:To investigate the influence of pinellia heart-draining Decoction, Licorice heart-draining Decoction, Fresh ginger heart-draining Decoction and its dismantlements on the amount of gastric mucus in rats. METHODS:20 different combination of Banxiaxiexin Decoction and its analogus according to the unform design layout, the amount of gastric mucus in rats was determinated. Stepwise regression analysis was adopted to estimate the relationship between the pharmacological data and compatibility. RESULTS:Rhizoma Coptidis could reduce the amount of gastric mucus remarkbably, the interaction of Rhizoma Pinelliae、Fructus Ziziphi Jujubae and Radix Glycyrrhizae could increase the amount of gastric mucus, and interaction was confirmed among different medicinal ingredients in prescription. CONCLUSION:Uniform design provides a referable exeperimental design for studying analogus decoction compatibility law.