RESUMEN
Objective: To compare the efficacy of felodipine versus propranolol in patients of essential hypertension for Serum cholesterol, LDL cholesterol and HDL cholesterol
Study Design: Randomized controlled study
Place and Duration of Study: This study was conducted at the Accident and Emergency Department, Bahawal Victoria Hospital, Bahawalpur and Ansari Private Clinic Model Town B Bahawalpur from 1[st] July 2015 to 30[th] September 2015
Materials and Methods: Total 90 patients with essential hypertension having age range from 30 to 50 years were enrolled in this study for three months. Patient were randomly divided into three groups I, II and III, each group comprising 30 patients. Group I patients were treated with felodipine, Group II patients were treated with propranolol and group III patients were treated with placebo. Effects of these drugs on Lipid profile [Serum cholesterol, HDL cholesterol and LDL cholesterol] were compared
Result: Felodipine, treated patients exhibited markedly significant fall in the serum cholesterol [P<0.01], highly significant fall at the level of LDL cholesterol [P<0.001] and non-significant effect in HDL cholesterol. Whereas propranolol treated patients showed highly significant increase of serum cholesterol [P<0.001], markedly significant increase in LDL cholesterol [P<0.01] and markedly significant decreased in HDL cholesterol [P<0.01]
Whereas comparison of two drugs Felodipine and Propranolol displayed a highly increased [P<0.001] serum cholesterol, LDL cholesterol and markedly increased [P<0.01] HDL cholesterol
Conclusion: Result of this study showing that comparing the two drugs felodipine had significantly decreased Serum cholesterol and LDL Cholesterol, whereas propranolol increased the Serum cholesterol, LDL cholesterol and decreased HDL cholesterol. So felodipine prove its merit over propranolol
RESUMEN
Introduction: Now a days Calcium channel blockers and Beta blockers are widely used for the treatment of essential hypertension. Beta blockers have been observed to increase the serum cholesterol, serum triglycerides and serum LDL cholesterol levels, calcium channel blockers have been noted to have a beneficial effect on lipid profile. Setting: In outpatient clinic of Bahawal Victoria Hospital, Bahawalpur Period: From 1[st] Sep 2003 to 31 Mar 2004 [three months]
Material and Methods: Blood pressure, systolic and diastolic, and lipid profile [Serum cholesterol, LDL cholesterol, HDL cholesterol and serum triglycerides] were investigated in patients receiving Amlodipine therapy. This was a 3 months follow-up study, which was carried on 90 patients. The effects of drugs were assessed at various time intervals. Second generation Calcium channel blocker, Amlodipine, which is widely used for treatment of Hypertension was selected to observe its effect on serum lipid profile in various patients
Results: The mean systolic and diastolic blood pressure decreased from 158 mm Hg and 104.4 mm Hg to 122.26 mm Hg and 38.56 mm Hg respectively after 90 days of treatment with Amlodipine. The fall in serum cholesterol level [mg/dl] and LDL-cholesterol [mg/dl] was from 188.13 and 125.40 to 170.76 and 105.7 after respectively after 90 days
Conclusion: Amlodipine significantly reduced blood pressure, decreased the level of serum cholesterol and LDL cholesterol but did not affect significantly the HDL cholesterol and serum triglycerides