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Rev. méd. Chile ; 131(5): 515-519, mayo 2003.
Artículo en Español | LILACS | ID: lil-356109

RESUMEN

BACKGROUND: Oropharyngeal candidiasis (OPC) and esophageal candidiasis (EPC) are frequent complications in AIDS patients. The use of Fluconazole, an effective and a low toxicity drug, has been associated to the emergency of secondary resistant strains. For this reason, in vitro antifungal susceptibility tests are necessary to predict a therapeutic failure. Etest is an easy to perform alternative test, that has showed a good agreement with the broth microdilution reference method (NCCLS, document M27-A). AIM: To measure the susceptibility of C. albicans isolates from AIDS patients complicated with OPC and EPC to Amphotericin B (AmB) and Fluconazole (Flu) using Etest. MATERIAL AND METHODS: Twenty strains from 20 AIDS patients were studied. AmB was tested in RPMI 1640 agar and Flu in Casitone agar. RESULTS: All studied strains showed minimal inhibitory concentrations (MICs) < 1 mg/mL for AmB. A highly resistant strain to Flu (> 256 mg/mL) was isolated from a patient previously treated with Flu. CONCLUSIONS: In AIDS patients with OPC and EPC, the susceptibility to Flu of the isolates should be screened, to detect resistant strains. Etest is a reliable alternative in these cases, for laboratories that cannot use the reference method.


Asunto(s)
Humanos , Masculino , Femenino , Antifúngicos , Candida albicans/efectos de los fármacos , Candidiasis/tratamiento farmacológico , Enfermedades del Esófago/mortalidad , Infecciones Oportunistas Relacionadas con el SIDA/tratamiento farmacológico , Antifúngicos , Anfotericina B/farmacología , Anfotericina B/uso terapéutico , Candida albicans/aislamiento & purificación , Candidiasis Bucal/tratamiento farmacológico , Enfermedades Faríngeas/tratamiento farmacológico , Enfermedades del Esófago/complicaciones , Enfermedades del Esófago/tratamiento farmacológico , Fluconazol/farmacología , Fluconazol/uso terapéutico , Infecciones Oportunistas Relacionadas con el SIDA/microbiología , Farmacorresistencia Fúngica , Pruebas de Sensibilidad Microbiana/métodos
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