Causes and management of cellulitis

Background: Cellulitis is a diffuse, deep, acute inflammation of the skin including the dermis and subcutaneous tissue. It often follows an acute or chronic trauma, and is an important cause of hospital admissions. About 10% of infections-related hospital admissions in the US annually are due to cellulitis. The most common cause of cellulitis is group A streptococci

Aim: of this review was to study the common causes of cellulitis, and understanding the approach to its management

Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 1983, through February 2017. The following search terms were used: cellulitis, soft tissue infection, etiology of cellulitis, investigation of cellulitis, management of cellulitis, resistant cellulitis

Conclusion: Cellulitis is a common cause of infection-related hospital admissions worldwide. Mild cases can resolve with empiric antibiotic treatment, whereas moderate or severe diseases are harder to treat and are associated with higher recurrence rates. Recurrence rates can be minimized by treating predisposing factors like obesity, lymphedema, and skin injuries

< The> risk of renal injury in infants associated with ibuprofen use: a systematic review

Background: More recently ibuprofen, was used for the indication of the patency of ductus arteriosus closure in preterm infants; this drug is associated similar side effects include cerebral, renal, and mesenteric circulation

Methods: An electronic search was carried out using search terms such as "renal failure", "kidney failure", "renal injury", ibuprofen, "side effects", "adverse effect", complications. The search in MEDLINE and EMBASE through PubMed search engine resulted in 31 articles. These articles were screened for eligibility criteria included studies aimed to assess renal injury caused by ibuprofen use in infants

Results: After exclusion of irrelevant duplicated and review studies, 12 studies were included in this review. Eight studies were randomized control, 3 retrospective evaluation and 1 retrospective cohort study. the effect of the treatment on the renal function there are two outcomes reported either reduction in serum creatinine or incidence of acute renal failure. Incidence of acute renal failure reported in 4 studies

Conclusion: Although renal failure was more common in infants receiving Indomethacin compared to Ibuprofen, oral Ibuprofen was less toxic to the kidneys than intravenous and the serum creatinine levels after treatment did not differ, this is not significant