RESUMEN
This study was designed to investigate the possible effect of exenatide [Glucagon like Peptide-1 receptor agonist] on liver injury [distant organ] induced by renal ischemia reperfusion [IR] in diabetic rats. In vivo renal IR was performed in both type 2 diabetic and normal rats. Each protocol comprised ischemia for 30 minutes followed by reperfusion for 24 hours and a treatment period of 14 days before induction of ischemia. Lipid peroxidation, xanthine oxidase activity, myeloperosidase activity and nitric oxide level in liver tissue were significantly increased [P<0.01], these biochemical parameters in treated rats compared to diabetic IR rats. Serum creatinine phosphokinase activity and liver function enzymes were also significantly normalized [P<0.001, P<0.001, respectively], after administration of exenatide. Exenatide exerted protective effect on exaggerated remote organ [liver] injury induced by renal IR in diabetes