Effects of a triphasic, low and high dose oral contraceptives on carbohydrate metabolism

The effect of a triphasic oral contraceptives, containing 30-40-30 ug ethinyl estradiol [EE] and 50-75-125 Levo-norgestrel [LNg], on carbohydrate metabolism was compared with that of a fixed low dose combination containing 30 ug EE plus 150 ug LNg, and that of a high dose one containing 50 ug EE and 500 ug dL-norgestrel [Ng]. The study included 30 women in each group at the same age. Fasting and post-prandial blood sugars were determined basally and after 6 and 12 months of pill taking. The high dose drug was the only one to cause a significant elevation in mean fasting sugar after 6 months, but by the end of one year the 3 drugs significantly elevated mean fasting sugar. Post-prandial sugar was significantly elevated by the 3 drugs after 6 and 12 months. The changes caused by the triphasic drug were the least changes

Placental bed changes in hypertensive pregnancy and its reflection on fetal outcome

Placental bed biopsy specimens were obtained under direct vision during cesarean section from 42 patients [10 normotensive, 20 pre-eclamptic, 2 eclamptic and 10 essential hypertension with pregnancy]. The mean gestational age was 38-40 weeks. Spcimens were examined histologically light microscope. Spiral artery changes in the normotensive pregnancy were compared with those in hypertensive pregnancy. The degree of impairement was proportioal to the severity of the disease. Typical physiological changes were present in cases of essential hypertension with pregnancy

value of the laparoscope in the diagnosis of polycystic ovary

In this paper we studied 171 patients with polycystic ovarian disease diagnosed by laparoscopy. The disturbances of the menstrual cycles varied between amenorrhoes, secondary or primary, oligohypomenorrhoea, menorrhagia or regular cycles. In performing laparoscopy 160 patients had general anesthesia and 11 patients had local anesthesia. Laparoscoy revealed that the polycystic changes of the ovaries were not always bilateral, but were sometimes unilateral. There were 141 patients with bilateral changes and 30 patients with unilateral changes in the left ovary. All the ovaries, however, showed a smooth, pearly, white thick surface with the loss of the surface indentations of the normal ovary