Assessment of acute primary angle closure glaucoma management

PURPOSE:To determine the outcomes of acute angle closure glaucoma management. METHODOLOGY:Case-control study using computer-aided imaging as a screening test in a given population. RESULTS:There is a wide variability in cup and disc areas among g normals CONCLUSION:C:D alone has a poor predictive value for diagnosing glaucoma.Optic disc size with C:D is just as sensitive and specific in screening for glaucoma.Cup and disc areas are positively correlated for normal and glaucoma suspects.

Chitosan biofilm for ocular surface reconstruction: An animal study

OBJECTIVE: To determine the effectivity of Chitosan in the reconstruction of conjunctival defect created during surgical removal MATERIALS AND METHODS: Preparation of Chitosan biofilm. Chitin was isolated and purified from giant tiger prawn (Penaeous monodon) exoskeleton waste and converted to a 97 percent deacetylated form by reaction with 40 percent NaOH then dissolved in 0.1M acetic acid forming a chitosan-acetate solution. The solution was poured into a petri dish and dried forming a film. Animal Study. Conjunctival defects were induced by excising the conjunctiva (6 x 6 mm) of 32 rabbit eyes. Sixteen experimental eyes received the chitosan biofilm sutured in continuous fashion using 8-0 conjunctiva, where the previous incision was made, were harvested and sent for histopathology to look for re-epithelialization and fibroblast formation. Wilcoxon Matched-Pairs Signed-Ranks Text was utilized in data analysis RESULTS: Epithelial growth was significantly higher in the Chitosan treated group as compared to the control (p0.05). Fibroblast formation was likewise significantly higher in the Chitosan treated group than in the control CONCLUSION: Chitosan is effective in promoting re-epithelialization and fibroblast formation and can thus be used as a possible alternative in ocular surface reconstruction. (Author)

Essential oil of Cymbopogon citratus (tanglad; lemon grass) as a potential antifungal topical eye medication: In vivo study

Preparation of the essential oil of lemon grass was done in collaboration with the Chemical and Minerals Department of DOST. Properly washed and air dried mature leaves of lemon grass were used. Essential oil was extracted by means of hydrodistillation wherein the cut leaves were placed in a 4 liter erlenmeyer flask filled with tap water which was sealed and connected to a Clevenger tube for collection. This was then dried with anhydrous sodium sulfate (Na2SO4). The percentage oil yield of the sample was computed in terms of volume per weight percent. Moisture of free oils were stored in amber colored bottles at 4 degrees centigrade A 1.17 percent has been extracted through this process. The oil obtained was subjected to bioassay gas chromatography. The gas chromatogram found that Citral was the major component with a concentration of 69.39 percent. The physical properties of lemon grass essential oil in Table 1 Antifungal sensitivities were determined with tube dilution methods. The MIC for Fusarium solani was determined at 625 ug/ml and the MFC was at 700 ug/ml. The MIC of Aspergillus was at 500 ug/ml and MFC was at 570 ug/ml.