RESUMEN
Objective: This study aims to determine the clinical features which are helpful as significant indicators in the diagnosis of malignant and nonmalignant nonodontogenic orofacial tumors. Materials and Methods: This was a prospective study performed on patients with swellings in the oral and maxillofacial region clinically suspicious of being tumors of nonodontogenic origin in a Nigerian Tertiary Health Institution. The statistical variables that were analyzed included patients' resume, clinical and radiological features as well as the histopathological diagnosis of the lesions. The level of significance was set at P < 0.05. Inferential analysis was done using Student's t-test, Chi-square, binary logistic regression, and adjusted odds ratio as appropriate. Results: There were forty patients histopathologically diagnosed as nonodontogenic tumors of the orofacial region. Twenty-five (62.5%) were females and 15 (37.5%) were males with mean age of 36 ± 21.9 years. Histopathological features showed three different categories of the lesions: Reactive and benign (nonmalignant) and the malignant lesions. Lymphadenopathy (P = 0.035) and nonmobility of the swellings (P = 0.029) were significant clinical indicators that were strongly associated with histological diagnosis of the malignant nonodontogenic tumors. Conclusion: This study showed that the nonodontogenic tumors occurred mostly in younger patients with a female preponderance. The mandible and the preauricular region were the most common sites. Lymphadenopathy and nonmobility of the swellings were strong clinical indicators for the diagnosis of the malignant nonodontogenic tumors
RESUMEN
Objective: Multifocal epithelial hyperplasia (MEH) or Heck's disease is an uncommon oral mucosa disease caused by the Human Papilloma Virus (HPV) especially subtypes 13 or 32. It is contagious with a tendency to be transmitted to other family mem bers. There is geographic hic regional variation in the frequency of occurrence of this condition. A careful clinical examination is required to arrive at the diagnosis. Histopathological review however can help to confirm the diagnosis of MEH. Molecular biology techniques like PCR or ISH are useful in isolating the HPV subtypes involved. This report aims to highlight the clinical features of MEH for accurate clinical diagnosis by Dental and Medical Practitioners Case Report: A documentation of a case of a 6-year-old Efik, Nigerian male child with extensive multiple oral mucosa lesion of 2 years' duration. The diagnosis of this case was based on the clinical presentation. The presence of multiple painless pink to whitish oral mucosa papules and nodules on the lips, labial and buccal mucosa was seen and a diagnosis of Multifocal Epithelial Hyperplasia was made. Conclusion: We report a case of MEH, a rare benign oral mucosal lesion in a 6 -year-old male of the Efik ethnic group in the south-south zone of Nigeria who presented with a 2year history of multiple lesions in the oral mucosa. It is important for Dental and Medical practitioners to be aware of this rare condition