Calciphylaxis: a diagnosis to be considered

Calciphylaxis, Calcific uremic artteriolopathy [CUA] is a rare but serious complication of end-stage renal disease [ESRD], though it can occur in non uremic. Its main presentation is skin changes and digital gangrene. We present a case of a 70 years old male who had a previous big toe amputation. He presented with acute heart failure syndrome, with fingers and toes gangrene which was mistakenly diagnosed as cyanosis. Following comprehensive assessment patient was diagnosed as having Calciphylaxis. Histological findings have shown intimal hypertrophy and diffuse calcification of the small arteries which further supported the diagnosis of CUA, calciphylaxis, complicating CRF