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Biol. Res ; 48: 1-6, 2015. graf, tab
Artículo en Inglés | LILACS | ID: biblio-950792

RESUMEN

BACKGROUND: Ruta graveolens L. (R. graveolens) is a medicinal plant employed in non-traditional medicines that has various therapeutic properties, including anthelmintic, and vasodilatory actions, among others. We evaluated the trachea-relaxant effects of hydroalcoholic extract of R. graveolens against potassium chloride (KCl)- and carbachol-induced contraction of rat tracheal rings in an isolated organ bath. RESULTS: The results showed that the airway smooth muscle contraction induced by the depolarizing agent (KCl) and cholinergic agonist (carbachol) was markedly reduced by R. graveolens in a concentration-dependent manner, with maximum values of 109 ± 7.9 % and 118 ± 2.6 %, respectively (changes in tension expressed as positive percentages of change in proportion to maximum contraction), at the concentration of 45 µg/mL (half-maximal inhibitory concentration IC50: 35.5 µg/mL and 27.8 µg/mL for KCl- and carbachol-induced contraction, respectively). Additionally, the presence of R. graveolens produced rightward parallel displacement of carbachol dose-response curves and reduced over 35 % of the maximum smooth muscle contraction. CONCLUSIONS: The hydroalcoholic extract of R. graveolens exhibited relaxant activity on rat tracheal rings. The results suggest that the trachea-relaxant effect is mediated by a non-competitive antagonistic mechanism. More detailed studies are needed to identify the target of the inhibition, and to determine more precisely the pharmacological mechanisms involved in the observed biological effects.


Asunto(s)
Animales , Ratas , Parasimpatolíticos/farmacología , Tráquea/efectos de los fármacos , Extractos Vegetales/farmacología , Ruta/química , Músculo Liso/efectos de los fármacos , Fármacos Neuromusculares Despolarizantes/farmacología , Cloruro de Potasio/farmacología , Furocumarinas/análisis , Quercetina/análisis , Rutina/análisis , Tráquea/cirugía , Técnicas In Vitro , Carbacol/farmacología , Extractos Vegetales/química , Cromatografía Liquida , Ratas Sprague-Dawley , Colinérgicos/farmacología , Concentración 50 Inhibidora , Componentes Aéreos de las Plantas/química , Contracción Muscular/efectos de los fármacos , Tono Muscular/efectos de los fármacos
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