RESUMEN
Increased plasma treponin T [CTnT] is frequently observed in end-stage renal failure patients. patients with end-stage renal disease have a high risk of premature death, mainly as a result of cardiovascular disease [CVD], which is not sufficiently explained. The objective of this study was to study the extent and pattern of increased cardiac treponin T [CTnT] in end stage renal failure patients on regular hemodialysis and to evaluate the usefulness and the prognostic value of CTnT as a predictor of subsequent cardiac events in those patients. This study was carried on [80] patients on regular hemodialysis [50] of them have no evidence of ischemic heart disease and [30] proved to have cardiac diseases, patients were followed up for 6 months and one year for any cardiac events. a] There is no correlation between CTnT level and blood urea, serum creatinine and blood sugar. b] CTnT levels are higher in ischemic group [mean level 0.11 microg/L] than in non ischemic group [mean level 0.08 microg/L]. c] More cardiac complications were observed in the cardiac group versus non cardiac patients. These complications were associated with higher levels of CTnT, in the cardiac group during the period of follow up 6 patients [20%] died, 3 [10%] suffer frequent anginal attacks, 4 [13.3%] suffer heart failure and 3 [10%] suffer myocardial infarction. In the non cardiac group during the period of follow up 9 patients [18%] died, 7 [14%] patients show ischemic changes in E-C-G follow up, 8 [l6%]suffer heart failure and 1 [2%] patients suffer myocardial infarction. Increased plasma cardiac treponin T [CTnT] is frequently observed in end stage renal disease patients without acute coronary disease. Increased [CTnT] appears to predict cardiac complications and predicts long and short term all cause mortality in hemodialysis patients. The CTnT predicts death and cardiovascular outcomes in clinically stable patients with end-stage renal disease. Because this protein is synthesized exclusively in myocardial cells, its predictive power for these outcomes may be because it reflects, besides cardiac ischemia, left ventricular [LV] mass, which is a strong predictor of cardiovascular death in this population per se