RESUMEN
Alkaptonuria is a rare autosomal recessive metabolic disorder that may present with multi-system involvement such as ochronotic arthropathy, renal, urethral and prostatic calculi, cardiac valvular lesions and pigmentation of the skin, sclera, cartilage and other connective tissues. An association of the disease with uveitis has never been reported. We report the first case of alkaptonuria with ochronotic arthropathy presenting with recurrent acute anterior uveitis as the initial manifestation. The possible common link with the HLA-B27 gene is discussed.
Asunto(s)
Enfermedad Aguda , Alcaptonuria/complicaciones , Antioxidantes/uso terapéutico , Ácido Ascórbico/uso terapéutico , Diagnóstico Diferencial , Antígeno HLA-B27/genética , Humanos , Masculino , Persona de Mediana Edad , Midriáticos , Ocronosis/complicaciones , Espondiloartropatías/complicaciones , Uveítis Anterior/etiologíaRESUMEN
Melioidosis is an acute infectious disease caused by a safety-pin-shaped gram-negative bacteria called Burkholderia pseudomallei. Here, we report the first case of melioidosis in a middle aged male agricultural worker, from Pondicherry. The isolation of this organism from subcutaneous nodules on the extensor aspect of his limbs underlines the diversity of its clinical presentation. Difficulty in identifying the organism which mimics any other non-fementing gram-negative bacilli (NFGNB) on cursory examination, highlights the importance of identification of NFGNB in endemic areas for specific treatment and prevention.