Multiple myeloma: treatment options for an incurable disease.

Multiple myeloma remains a challenge for the treating physician, with extremely low complete response rates (5-10%) to conventional induction therapy. High dose therapy with autologous hematopoietic stem cell transplant results in improved response, event-free and overall survival and should be considered the standard of care for patients who are candidates for transplantation. Several newer treatment option are now available.

Comparative study between modified Freyer's prostatectomy, classical Freyer's prostatectomy and Millin's prostatectomy.

Classical Freyer's method was modified in which, prostatic fossa was packed after the enucleation of the gland for hemostatic purpose; and the pack and suprapubic drain were brought out laterally. The pack was removed after 48-72 hours postoperatively and catheter was introduced per urethrum for early closure of suprapubic ostomy. Fifty such cases of Modified Freyer's prostatectomy were compared with cases of classical Freyer's prostatectomy (n = 25) and Millin's prostatectomy (n = 25). The duration of surgery and requirements for perioperative blood transfusion were found to be less with our method.