Nanotechnology and pharmaceutical inhalation aerosols.

Pharmaceutical inhalation aerosols have been playing a crucial role in the health and well being of millions of people throughout the world for many years. The technology's continual advancement, the ease of use and the more desirable pulmonary-rather-than-needle delivery for systemic drugs has increased the attraction for the pharmaceutical aerosol in recent years. But administration of drugs by the pulmonary route is technically challenging because oral deposition can be high, and variations in inhalation technique can affect the quantity of drug delivered to the lungs. Recent advances in nanotechnology, particularly drug delivery field have encouraged formulation scientists to expand their reach in solving tricky problems related to drug delivery. Moreover, application of nanotechnology to aerosol science has opened up a new category of pharmaceutical aerosols (collectively known as nanoenabled-aerosols) with added advantages and effectiveness. In this review, some of the latest approaches of nano-enabled aerosol drug delivery system (including nano-suspension, trojan particles, bioadhesive nanoparticles and smart particle aerosols) that can be employed successfully to overcome problems of conventional aerosol systems have been introduced.

The effect of carbon dioxide laser on acid resistance of human tooth enamel: an evaluation by wet chemical analysis and scanning electron microscopy.

The use of the laser in improving acid resistance of tooth enamel has captured the imagination of most researchers. Man's susceptibility to dental caries presents itself as one of the most complicated problems to solve. The carbon dioxide laser at a wavelength of 10.6 microns is highly efficient for dental purposes as this wavelength is close to optimum absorption of dental enamel. A study was carried out using a pulsed carbon dioxide laser to find the effects of laser beam on human tooth enamel in an energy range of 2-20 J/cm2 at a pulse rate of 5 Hz. The effective resistance to acid was determined by wet chemical analysis whereas superficial changes seen on the surface were determined using the scanning electron microscope.

Craniofacial excision for recurrent osteogenic sarcoma of maxilla.

Two cases of recurrent osteogenic sarcoma of the antro-ethmoidal complex treated at our hospital by a craniofacial resection are presented. The imperative need to treat osteogenic sarcomas of the maxilla primarily by a radical approach such as a craniofacial resection is emphasized.

Recombinant alpha-interferon therapy in multiple myeloma.

Three patients with multiple myeloma were treated with recombinant alpha-interferon (r IFN-alpha 2b Intron AR) along with combination chemotherapy i.e. melphelan and prednisolone. In one case it was given as an initial therapy, while the other two patients had refractory and relapsing disease respectively. IFN-alpha 2b was given in the dose of 2 x 10(6) Mu/m2 by subcutaneous injection thrice in a week for six months in two patients and for three months in one patient. All three patients experienced improvement in bone pains; partial response with reduction in the paraprotein level was seen in one patient; while there was no radiological, biochemical or haematological improvement in two patients. Side effects noted were flu like syndrome in all three patients and urticaria in one patient. They were treated symptomatically and did not require cessation of interferon therapy.