RESUMEN
Background:The double strand break repair pathway, comprising XRCC2 and XRCC3 has crucial role in maintenance of genomic stability and prevention of tumor initiation and progression. Therefore, sequence variants of such DNA repair genes may compromise individual's DNA repair capacity and can influence risk of developing breast cancer. Method and Results:To estimate the impending effect of XRCC2 (Arg188His) and XRCC3 (Thr241Met) polymorphisms on breast cancer, 133 breast cancer patients and 154 healthy controls were evaluated by PCR-RFLP method. In the present study, it was noted that there was no significant correlation between these polymorphisms and breast cancer risk. However, within patient group, significant association of XRCC2 variants with PR negative breast cancer was detected. Further, patients with XRCC2 variant genotypes were also at high risk of developing TNBC and Her2 enriched subtypes as compared to luminal A subtype. Significant relation was also obtained between XRCC3 variants and large sized and infiltrative breast tumors. Conclusion: These noteworthy observations demonstrate potential involvement of XRCC2 and XRCC3 polymorphisms in pathophysiology of breast cancer.
RESUMEN
176 chromium-exposed and 30 control subjects were selected for this study. Blood samples (3 ml) were collected for the estimation of chromium. The data on chromium concentration indicated a significant higher level of chromium in the blood of the exposed workers as compared to the control. There was no significant correlation between the mean blood and environmental chromium level. This study suggests that exposure to chromium may have some effect on the health of workers, even though the dose response relationship could not be established between blood chromium and environmental chromium levels. This study suggests that exposure to chromium may have some effect on the health of workers, even though the dose response relationship could not be established between blood chromium and environmental chromium levels. Study also indicates that the environmental levels to Cr are well below the permissible levels at all the sites of the industry at the time of survey even though the blood Cr levels were observed high in 14.8% of workers and some of them were having Cr related morbidity. Therefore, preventive and engineering control measures are suggested to minimize the chromium exposure in the chromium based industry located in Gorwa industrial estate at Baroda, Gujarat. About three months period was taken to complete this study.