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Introduction: Stroke is the common cause of severe disabilityand death worldwide. Study aimed to evaluate etiological,demographic, clinical course and identification of risk factorsin acute ischemic cerebrovascular stroke.Material and methods: A prospective study of 46 patientsof Ischemic cerebrovascular stroke conducted at MedicalCollege, Vadodara during January 2014 to November 2014.All Patients were subjected to Personal biodata and detailedclinical assessment with written consent. All were sent forroutine blood investigations including Lipid profile, chest xray PA view, Electrocardiography, 2D Echo and CT Scan. AllData were analysed by using Microsoft excel software.Results: In our study, most common age group was 55 to64 yrs (mean age 55.5yrs) with males predominance wasobserved (52%). Among males, 26 (56.53%) patients weresmokers while 18 (39.13%) males were alcoholic. Amongst46 patients, 55% and 35% found to be hypertensive andDiabetic respectively. 24% Patients had positive familyhistory of Hypertension. In our study, 54.3% had normalserum cholesterol level between 150 to 199 mg/dl whileHypertriglyceridemia and low HDL was found in 17.4% and26% respectively. Most common documented risk factors forstroke were age, smoking, hypertension and Diabetes Mellitus.Most of Patients presented with limb/motor weakness (86.9%)followed by speech disturbance and loss of consciousness at41.3% and 34.7% respectively. Hospital outcome was good.Conclusion: Ischemic stroke entails high socioeconomicburden due to increased morbidity and mortality. Age,Smoking, Hypertension and Diabetes are importantatherosclerotic risk factors in our study. Early Identification,treatment and prevention of risk factors can decline theincidence, complications and related mortality. So Physicianhave a important role in stroke prevention by encouraging thereduction in risk factors.
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Background: Under nutrition continues to be an important public health problem, inspite of several nutrition intervention programs in India. The present study was carried out to know the prevalence of underweight, stunting and wasting among 6 months to 5 years children and to assess nutrition status and related factors among study population.Methods: A community based cross sectional study using stratified random sampling. Total 165 samples were taken from 5 field practice area of B. J. Medical College, Ahmedabad. From each area 33 random samples were taken.Results: Out of 165 children 80 and 85 were male and female. The prevalence of underweight, stunting and wasting was 45%, 46% and 29% respectively. SE class IV and V, low birth weight, higher birth order, late age of starting complementary feeding, parents education were significantly associated with undernutrition.Conclusions: The risk of undernutrition is higher in field practice area of B. J. Medical College, Ahmedabad. There is a need to strengthen promotion of maternal nutrition; maternal education and improving household socio-economic condition along with health care services may improve nutritional status of children.
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Nitrofurantoin is a broad-spectrum bactericidal antibiotic that affects both Gramnegative and Gram-positive bacteria. Nitrofurantoin exhibits bacteriostatic or bactericidaleffects by inhibiting the synthesis of DNA, RNA, protein and cell wall synthesis. Nanocrystals ofNFT were prepared by Cold High Pressure Homogenization Technique. NFT was dispersed inaqueous surfactant solution containing Poloxamer 188, PVPK 30 and HPMC E3 undercontinuous stirring. Poloxamer 188 was used as a surfactant for the preparation of the NCsFormulation NC9B3 have mean particle size 231 ± 9nm with Polydispersity index 0.09 ± 0.02which indicates very narrow particle size distribution. % Entrapment efficiency was 98.3± 0.7Slow drug release profile indicates the homogeneous dispersion of NFT in lipid matrix. NCshave crystalline nature with rough surfaces which has been confirmed using SEM analysis.XRPD spectra show the reduction in crystalline behaviour of the drug and the lipid afterformation of the NCs. There was no significant change in the mean particle size andPolydispersity index after 6 month storage at 25°C/60% RH
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Introduction: Chronic acquired hepatocerebral degenerationis a rare disorder typically accompanied by cognitivedisturbances and parkinsonian features secondary to liverdisease. It is the deposition of manganese in the basal ganglialeading to T1 hyperintensity on MRI of these patients and theresulting clinical features. Familial association is found insome cases.Case report: Here, we report the case of a 32 year old postpartum female who presented with tremors and historyof liver disease. MRI of the brain showed symmetrichyperintensities in globus pallidi, substantiae nigrae, andsuperior cerebral peduncles in T1-weighted images. Althoughliver transplantation is the best modality of treatment atpresent, the patient showed improved on treatment withLevodopa+carbidopa.Conclusion: It is important to recognize this disease entity forsymptomatic relief of the patient. However further research isrequired for better management.
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Background: Coronary heart disease is responsible for more deaths and disability in developed world, now affecting developing countries. The present study aims to evaluate clinical course, identification of risk factors and outcome of unstable angina.Methods: An observational study of 30 days follow up of 100 patients of newly diagnosed UA was conducted. Sociodemographic, clinical, family h/o risk factors, dietary, other lifestyle characteristics, Standard 12 lead ECG and BP recorded. Blood was collected for routine investigations and cardiac enzymes (serum Trop-T Quantitative and CPK-MB levels). Blood was Collected in fasting state (glucose and lipid profile) and after4 hrs of routine lunch for Triglyceride measurement. Patients were observed for complications after hospital discharge on OPD basis.Results: Middle aged patients are more likely to be selected for study (mean age 51.2±6.4) being M:F ratio of 1.5:1. Amongst males 82%were smokers. 68 patients were having Postprandial triglyceride >160 mg% while 58 had low HDL levels(<40mg%).Amongst 100 patients, 68% and 62% found to be Diabetic and hypertensive respectively. Hospital outcome was good.81.2% patients remained free of cardiac events during 30 days follow up while 13.7% admitted with recurrent angina. No mortality during entire study period.Conclusions: Ischemic heart disease entails high socioeconomic burden due to increased morbidity and mortality. smoking, hypertension, diabetes mellitus and dyslipidemia are important cardiovascular risk factors in present study. Postprandial hypertriglyceridemia was found to be strongly associated with Diabetes Mellitus. Postprandial hypertriglyceridemia despite normal fasting triglyceride may be independent risk factor for atherosclerosis subsequently ischemic heart disease. Early identification, treatment and prevention of cardiovascular risk factors can decline the incidence, complications and related mortality.