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Background: Preterm premature rupture of membranes (PPROM) is rupture of fetal membranes prior to labor in pregnancies between 28-37 weeks. PPROM is associated with significant maternal and neonatal morbidity or mortality. The present study was conducted to evaluate risk factor and etiology of PPROM and its fetomaternal effect in tertiary care hospital.Methods: A cross-sectional study was conducted in the department of obstetrics and gynaecology, SMS Hospital, Ahemdabad. From August 2023 to February 2024.The study included 50 pregnant women between 28-37 weeks gestation with PPROM were subjected to detailed history and examination. Each patient was followed till her delivery and fetomaternal outcome was recorded.Results: PPROM is a fair complication of pregnancy. 80% were belongs to 20-29 age, 70% were unbooked, 76% from low SE-class, 68% with gestational age of 34-36 weeks. Vaginal delivery was common 58%. The babies born to mothers with PPROM more in weight of 2-2.5 kg (48%). 34 had no risk factors to develop PPROM. Most common etiology for PPROM infection 16% and malpresentation 10%. Most of the mothers with PPROM had no complications. 17 (34%) babies required NICU admissions for complaints of premturity, respiratory distress, birth asphyxia, and sepsis. RDS was most common neonatal complication. 2 neonatal deaths in this study due to RDS and prematurity.Conclusions: Effective PPROM Mx involves evaluating the risks and advantage of conservative Mx strategies. Whenever possible, Rx should be focused towards prophylactic use of antibiotics and steroids during pregnancy can reduce fetal and mother morbidity and mortality. Termination of pregnancy should be considered at the 1st sign of chorioamnionitis.
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Background: Iron deficiency anemia during pregnancy is a serious global concern specially in developing country, which is preventable with effective measures. In women who cannot tolerate oral iron or have moderate to severe anemia, parenteral iron in the form of iron sucrose or ferric carboxymaltose can be very much useful. This study aimed to compare efficacy and safety of iron sucrose and ferric carboxymaltose in iron deficiency anemia during pregnancy.Methods: This prospective interventional comparative study was conducted during May 2016 to April 2018 at tertiary care hospital and total 100 antenatal women from 28 to 34 weeks of gestation having moderate to severe anemia were included in this study and all women were divided in to 2 groups randomly and were given either iron sucrose or ferric carboxymaltose according to iron requirement. Rise in haemoglobin and serum ferritin were noted and data analysed statistically.Results: The mean rise of haemoglobin with iron sucrose was 1.8 gm% and with ferric carboxymaltose was 2.6 gm%. The mean rise of serum ferritin with iron sucrose was 82.4 ng/ml and with ferric carboxymaltose was 100.9 ng/ml. Other than minimal local reaction one woman had developed severe anaphylactic reaction after receiving iron sucrose.Conclusions: Intravenous ferric carboxymaltose is better and safe molecule than iron sucrose and it has advantage of ability to administer large dose in single sitting which reduce overall cost of therapy. Hence ferric carboxymaltose is a drug of choice as parenteral iron therapy in iron deficiency anemia during second trimester of pregnancy.