NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori

BACKGROUND: Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TLR4, TLR5, NOD1 and NOD2 genes are associated with gastric cancer, in particular in individuals infected with H. pylori. RESULTS: A case-control study of 297 gastric cancer patients and 300 controls was performed to assess the association of 17 polymorphisms. Analyses performed under the allele model did not find association with gastric cancer. However, NOD1 rs2075820 (p.E266K) showed association with intestinal-type gastric cancer among H. pylori infected subjects (OR = 2.69, 95% CI 1.41-5.13, p = 0.0026). The association was not statistically significant in diffuse-type gastric cancer cases (OR = 1.26, 95% CI 0.63-2.52, p = 0.51). When the analyses were performed in patients carrying H. pylori strains harboring the cag pathogenicity island (cagPAI), we noticed significant association with NOD1 rs2075820 (OR = 4.90, 95% CI 1.80-3.36, p = 0.0019), in particular for intestinal-type gastric cancer cases (OR = 7.16, 95% CI 2.40-21.33, p = 4.1 × 10- 4) but not among diffuse-type gastric cancer cases (OR = 3.39, 95% CI 1.13-0.10, p = 0.03). CONCLUSIONS: NOD1 rs2075820 increases the risk of intestinal-type gastric cancer among individuals infected with H. pylori, particularly in those harboring the cagPAI.

Niveles de insulina y hormona de crecimiento en niños con retraso pondoestatural de causa nutricional / Insuli and growth hormone levels in children with pondostatural retardation due to nutritional cause

Se presentan los resultados del estudio de la secreción de insulina y hormona de crecimiento en 20 niños con antecedentes de DPE y retraso pondoestatual actual de causa nutricional. Se realizó, en pacientes y controles prueba de tolerancia a la glucosa, en la cual se midió: glicemia, insulina, área total de glicemia y de insulina y constante K. al evaluar estos resultados no se encontró alteración en el metabolismo de hidratos de carbono. Se analizó también en estos niños la secreción de GH a través de la prueba de sensibilidad a la insulina. Se concluyó que nuestros pacientes tenían una deficiencia parcial de GH; a su vez se insiste en la necesidad de la evaluación de esta condición en todo niño con antecedentes de DPE y retraso estatural importante