RESUMEN
Goal : This is a subjective survey to assess the knowledge, awareness, and practices (KAP) of physicians while prescribing Proton pump inhibitors (PPI) in acid peptic disorder (APD) patients in India. Background : APD represents a variety of gastric anomalies in which PPIs form the mainstay of management. Many of the APD patients are associated with comorbidities, resulting in polypharmacy and increased risk of drugdrug interactions. Therefore, it is essential that physicians be aware of PPI drug interactions while prescribing them to patients with comorbidities. In developing countries like India, studies assessing the KAP of Physicians are limited. Study Design : This questionnaire-based study consisted of 3 domains: (A) Study objectives and consent; (B) Participants’ socio-demographic details; (C) Questions on KAP of Physicians around various aspects of APD management and PPI usage. Results : A total of 110 Physicians completed the survey. 92% observed stress as the most common risk factor; Obesity (46), Diabetes Mellitus (41%) and Cardiovascular Disease (33%) as the most frequent comorbidities, in APD. Almost all Physicians (99%) considered patient’s comorbidity important while choosing PPI. 84% participants felt that anticoagulants when co-prescribed with PPI have higher chance of drug-drug interactions. 60% ranked Rabeprazole in the top, in terms of safety and tolerability among PPIs. Conclusion: The present study mapped the awareness of Indian Physicians on APD, PPI usage, their adverse effects, drug-drug interactions; patient compliance and satisfaction with PPIs. These findings can be used to plan future interventions targeting HCPs, to ensure safe and appropriate use of PPIs
RESUMEN
Stevens-Johnson syndrome (SJS) is a rare consequence of hypersensitivity reaction precipitated by certain drugs and viral infections. It is an idiosyncratic drug reaction usually associated with drugs like anti-epileptics, non-steroidal anti-inflammatory compounds and antibiotics. The overall incidence of this entity is very low and is life-threatening if undiagnosed and untreated. The syndrome is characterized by purpuric macules and bullous eruptions involving the mucous membrane which may be followed by systemic manifestations. The mechanism of SJS due to drugs is not fully defined. Delayed Hypersensitivity reaction mediated by T lymphocytes in response to a drug is thought to be responsible. Here authors present a case of SJS induced by phenytoin in an adult male. The case warrants the need of adopting a meticulous approach while prescribing phenytoin. The case is being reported to accentuate the importance of adverse drug reactions and to emphasize the importance of reporting such reactions ensuring efficient pharmacovigilance.