Seroprevalence of hepatitis A antibodies in a group of normal and Down Syndrome children in Porto Alegre, Southern Brazil

The high incidence of Hepatitis A and B in institutionalized patients with Down Syndrome (DS) is not fully understood. Under poor hygienic conditions, immunological alterations might predispose individuals to these infections. Sixty three DS children between 1 and 12 years old living at home with their families were examined for anti-HAV and compared to age-matched controls (64 healthy children). This cross-sectional study was carried out from May, 1999, to April, 2000, at the Hospital de Clínicas of Porto Alegre, southern Brazil. Groups were compared in terms of age, sex, skin color, and family income (> R$ 500 and < R$ 500/ month) by the chi-square test, with Yates' correction and for the prevalence of anti-HAV (Fisher's exact test). In the DS group (n=63), the mean age was 4.4 ± 3.3 years, 94 percent of the patients were white and 51 percent were female. Family income was <= R$ 500/month in 40 cases (63 percent). In the control group (n=64), the mean age was 4.8 ± 2.7 years, 81 percent of the patients were white and 56 percent were female. Family income was <= R$ 500 in 20 patients (31 percent). DS children's families had a significantly lower income (P<0.0005). In the DS group there were 6 positive (9.5 percent) anti-HAV cases, and all came from low-income families (less than R$ 500/ month). In the control group, 3 cases (4.7 percent) were positive for anti-HAV (two were from a low-income family and one was from a higher income family). These differences were not significant. Our data indicate that Hepatitis A is not a special risk for mentally retarded DS outpatients, even in a developing country like Brazil

Síndrome hepatopulmonar / Hepatopulmonary syndrome

A presente revisäo enfatiza os aspectos relacionados às alteraçöes pulmonares subseqüentes à hepatopatia crônica, mais recentemente chamada síndrome hepatopulmonar, que se caracteriza por presença de doença hepática, associada a aumento do gradiente alvéolo-arterial e dilataçöes vasculares intrapulmonares. Säo abordados aspectos históricos bem como relacionados à fisiopatogenia e métodos diagnósticos empregados. O emprego de gasometria arterial em repouso e com oxigênio a 100 por cento para excluir "shunt" intrapulmonar assim como o emprego do ecocardiograma com contraste para avaliar o tipo de "shunt" säo opçöes diagnósticas menos invasivas que a arteriografia pulmonar. A difusäo com monóxido de carbono pode ser...

Efeito da colchicina sobre a cirrose hepática, em ratos, induzida por tetracloreto de carbono / Effect of colchicine on hepatic cirrhosis, in rats, induced by carbon tetrachloride

Os autores avaliam o efeito da colchicina sobre a cirrose, em ratos, induzida por tetracloreto de carbono (CCI4). Ratas Wistar foram divididas em grupos controles e em grupos tratados com colchicina, 10ug/100g/dia, e CCI4, 5ug/100g/dia, de colchicina e CCI4 ou apenas CCI4. Foi verificado que os animais que receberam CCI4 isolado ou associado à colchicina mostraram aumento da atividade da TGO, TGP e FA e reduçäo nos níveis séricos de albumina. O exame anatomopatológico do fígado dos animais desses grupos mostrou a presença de infiltrado inflamatório, esteatose, necrose, fibrose, proliferaçäo dos ductos biliares e regeneraçäo nodular. Além disso, nos rins desses animais foi detectada nefrite intersticial leve. Näo houve alteraçöes, entre os diferentes grupos, em relaçäo aos eletrólitos, uréia e creatinina