Effect of brain natriuretic peptide on dehydration- or angiotensin II- induced water intake in rats

The present study was performed to evaluate the effect of 3 rdV injection on water intake of brain natriuretic peptide (BNP), which is structurally different from the atrial natriuretic peptide. VNP was recently isolated from porcine brain and appears to have a different precursor than the family of atrial natriuretic peptides. Central administration of BNP 3rdV decreased water intake. At a dose of 2.0 mmol/rat, BNP partially inhibited dehyfration-induced water intake and completely blocked the stimulatory effect of 478 pmol/rat angiotension II in rats