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Braz. j. infect. dis ; 22(2): 142-145, Mar.-Apr. 2018. tab
Artículo en Inglés | LILACS | ID: biblio-1039213

RESUMEN

ABSTRACT The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a non-polarized cytokine response of the TH1 and TH2 profiles.


Asunto(s)
Humanos , Femenino , Adulto , Infecciones por VIH/inmunología , Citocinas/inmunología , VIH-1 , Sobrevivientes de VIH a Largo Plazo , Linfocitos T CD4-Positivos/inmunología , Infecciones por VIH/sangre , Infecciones por VIH/virología , Células Th2/inmunología , Células TH1/inmunología , Linfocitos T CD8-positivos/inmunología , Carga Viral , Terapia Antirretroviral Altamente Activa , Inmunidad Celular/inmunología
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