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Artículo en Inglés | IMSEAR | ID: sea-31727

RESUMEN

In the late summer (rainy season) of 1987, a sharp outbreak of fever of unknown origin (FUO) in rural southern Thailand was investigated by a field epidemiology team. In a random survey of households, 40 percent of the children and 20 percent of adults were reported to have had febrile illnesses within the last month. There was at least one death, possibly from Reye's syndrome. Testing 34 pairs of acute and convalescent sera showed significant HI antibody titer rises to influenza A (Taiwan/(H1N1) (9 cases) and dengue virus (12 cases). Testing 79 single sera with the antibody capture ELISA test for dengue, revealed that 23 percent had high titers in the IgM serum fraction suggesting recent infection. There were also six antibody titer rises to coxsackie B viruses, three from well controls. Dengue has previously been observed as a cause of FUO in rural areas in the tropics, but finding a combined epidemic of dengue and influenza was unexpected. With cooperative villagers, adequate personnel and laboratory support, especially the antigen capture ELISA test for dengue infections, it is feasible to successfully investigate disease outbreaks with serologic methods in remote villages.


Asunto(s)
Virus Chikungunya , Infecciones por Coxsackievirus/diagnóstico , Dengue/diagnóstico , Brotes de Enfermedades , Enterovirus Humano B , Ensayo de Inmunoadsorción Enzimática , Femenino , Fiebre de Origen Desconocido/epidemiología , Humanos , Subtipo H1N1 del Virus de la Influenza A , Virus de la Influenza A , Gripe Humana/diagnóstico , Masculino , Población Rural , Tailandia/epidemiología , Infecciones por Togaviridae/diagnóstico
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