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Acta cir. bras ; 35(3): e202000301, 2020. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1130626

RESUMEN

Abstract Purpose: To analyze the serum levels of nitric oxide and correlate them with the levels of thiobarbituric acid reactive substances (TBARS) in liver, brain and spinal cord of animals using L-NAME and treated with hydroxyurea. Methods: Eighteen male albino Wistar rats were divided into three groups. NG-nitro-L-arginine methyl ester (L-NAME) was intraperitoneally administered to induce oxidative stress. TBARS and plasma nitric oxide levels were analyzed in all groups. Histopathology of the liver and vascular tissue was performed. Results: Statistically significant differences were seen in liver, brain and spinal cord TBARS levels. Conclusions: Following the use of L-NAME, hepatic tissue increased the number of Kupffer cells as oxidative stress and inflammatory response increased. The use of L-NAME caused an increase in lipid peroxidation products and, consequently, in oxidative stress in animals. Hydroxyurea doses of 35 mg / kg / day reduced TBARS values in liver, brain and spinal cord.


Asunto(s)
Animales , Masculino , Ratas , Médula Espinal/metabolismo , Encéfalo/metabolismo , Estrés Oxidativo/fisiología , Hidroxiurea/uso terapéutico , Anemia de Células Falciformes/tratamiento farmacológico , Hígado/metabolismo , Ratas Wistar , NG-Nitroarginina Metil Éster , Modelos Animales de Enfermedad , Anemia de Células Falciformes/fisiopatología , Anemia de Células Falciformes/metabolismo
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