RESUMEN
In this study, Absorption factor method have been developed and validated for the simultaneous determination of perindopril erbumine and amlodipine besylate in their combined pharmaceutical formulation dosage form. Absorption factor method was performed for perindopril erbumine and amlodipine besylate at wavelength maxima 215 nm and 237 nm respectively. Amlodipine besylate was show liner at 237 nm but Amlodipine besylate also showed absorbance at 215nm and give interference in determination of Perindopril erbumine. Quantitative estimation of Perindopril erbumine was carried out by subtracting interference of Amlodipine besylate using experimentally calculated absorption factor. Result of analysis was validated by statistically. The result of the studies showed that the proposed Spectroscopic method is simple, rapid, precise and accurate, which can be used for the routine determination of Perindopril erbumine and Amlodipine besylate in bulk and in its pharmaceutical formulation.