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Objective To observe the clinical effect of leflunomide combined with total glucosides of paeony (TGP) on rheumatoid arthritis (RA).Methods From September 2014 to June 2016,83 RA patients in Jiuquan People's Hospital were selected in the research,and according to time sequence seeing doctors,the patients were divided into control group (41 patients) and treatment group (42 patients).The patients of the two groups were orally given leflunomide (20 mg,1 time/d),while the treatment group was added with TGP (0.6 g,3 times/d).The patients of the two groups were treated for one month.The changes of clinical indicators such as RF,ESR,CRP,2-dimer of the two groups before and after treatment were observed.Results Before treatment,the RF,ESR,CRP,2-dimer between the two groups had no statistically significant differences (all P ＞ 0.05).After treatment,the RF,ESR,CRP,2-dimer of treatment group were (76.9 ±25.6)U/L,(18.5 ±6.3)mm/h,(15.4 ±6.3) rmg/L,(5.22 ±4.65) mg/L,respectively,which of the control group were (99.6 ±32.7)U/L,(27.8±8.6) mm/h,(21.7 ±7.8) mg/L,(14.08 ±5.76)mg/L,respectively,the differences between the two groups were statistically significant (t =3.480,5.230,4.680,4.513,all P ＜ 0.05).The total effective rate of the treatment group was 83.33 ％,which was higher than 58.54％ of the control group,the difference was statistically significant (x2 =5.330,P ＜ 0.05).Conclusion The clinical effect of leflunomide combined with TGP in the treatment of RA is better than leflunomide.
RESUMEN
Objective To observe the efficacy of electroacupuncture in improving discomforts during and after oocyte retrieval, for providing scientific and significant clinical evidence for the application of electroacupuncture to oocyte retrieval.Method A hundred and thirty-four outpatients receiving IVF-ET fertility treatment were randomized into a treatment group and a control group, 67 in each group. The two groups both received muscular injection with Sauteralgyl 50 mg. Additionally, the treatment group was also given acupuncture at Baihui (GV20), Uterus (MA-TF, right ear), Tengtong (Extra, right), Sanyangluo (TE8, right), and Zusanli (ST36). When needling qi arrived, Tengtong (Extra) and Sanyangluo (TE8) were connected to SDZ-2 electroacupuncture apparatus. The needles were removed at the end of oocyte retrieval. For patients in the control group, oocyte retrieval was conducted 30 min after injection with Sauteralgyl. The operation duration was recorded; blood pressures before injection and at the end of surgery were measured; discomforts including dizziness, nausea, vomiting, perspiration, dry mouth, palpitation, and abdominal distension during operation were observed; discomforts (dizziness, nausea, vomiting, abdominal pain, and lassitude) 0.5 h, 1.5 h, and 2 h after operation were observed.Result The difference in comparing oocyte retrieval duration was statistically significant between the two groups (P＜0.05); there were significant differences in comparing the occurrence rates of dizziness, perspiration, nausea, and palpitation during operation between the two groups (P＜0.05); there were significant differences in comparing dizziness, vomiting, nausea, abdominal pain, and lassitude between the two groups 0.5 h, 1 h, 1.5 h, and 2 h after operation (P＜0.05). The inter-group differences in dizziness, vomiting, nausea, abdominal pain, and lassitude were statistically significant after operation (P＜0.05).Conclusion Electroacupuncture is effective in relieving discomforts during and after oocyte retrieval under transvaginal ultrasound.