Establishment of low-selenium culture conditions for in vitro cell experiment: a review / 中华地方病学杂志

Selenium is an essential trace element in many living organisms. Selenium deficiency inhibits cell differentiation and cell cycle progression, induces apoptosis and increases the virulence of certain viruses. In addition, selenium deficiency is an important etiology of Keshan disease and a risk factor for cardiovascular disease. Low selenium studies based on in vitro cell experiments are widely used. However, there is currently no clear and unified way to establish in vitro low-selenium conditions. In this paper, we have reviewed the progress on establishment of low-selenium conditions in vitro and its applications, so as to provide reference for subsequent study.