Research progress of HOX gene and gynecologic tumor / 实用肿瘤学杂志

The homeobox(HOX)gene is a special type of transcriptional regulator that plays an important role in physiologi-cal regulation mechanisms such as embryonic development,cell growth,differentiation and migration.Recent studies have found that HOX gene expression is abnormal and affects the occurrence and development of tumor.This review summarizes the progress of HOX gene and gynecologic oncology including cervical cancer,endometrial cancer and ovarian cancer,and the instruction and application of HOX gene in the treatment of cancer.We are making the guiding direction of exploring HOX gene through summarizing the existed re-search reports in order to alleviate the pain of gynecological cancer patients.