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ABSTRACT Introduction: Volleyball demands from athletes in continuous training a strong engagement and the use of sport endurance techniques, and their relaxation after training is indispensable. Objective: This paper investigates whether relaxation training after volleyball is beneficial in the competitive levels of volleyball players. Methods: 60 volleyball players aged 20-23 years were selected as participants in the experiment. They received relaxation training for 8 weeks, and heart rate changes were recorded before and after relaxation. Results: The heart rate of athletes in a resting state before training changed from 79.93 in the first week to 81.07 in the eighth week; after volleyball practice, the heart rate of athletes before relaxation varied from 136.13 to 140.73 from the first week to the eighth week; after the introduction of relaxation training, the heart rate of athletes was 84.71, and the minimum heart rate recorded was 80.74. It can be seen that relaxation training allows athletes to recover quickly to a normal state and achieve the goal of relaxation. Conclusion: Adding a relaxation training program to relieve fatigue after volleyball showed a useful for improving the performance of volleyball players. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
RESUMO Introdução: O voleibol exige dos atletas em formação contínua um forte engajamento e o uso de técnicas de resistência ao esporte, sendo indispensável o seu relaxamento após o treino. Objetivo: Este artigo investiga se o treinamento de relaxamento após o voleibol é benéfico nos níveis competitivos dos jogadores de voleibol. Métodos: 60 jogadores de voleibol de 20 a 23 anos de idade foram selecionados como participantes do experimento. Eles receberam treinamento de relaxamento por 8 semanas, registrando-se as alterações do ritmo cardíaco antes e depois do relaxamento. Resultados: O ritmo cardíaco dos atletas em estado de repouso antes do treinamento mudou de 79,93 na primeira semana para 81,07 na oitava semana; após a prática do voleibol, o ritmo cardíaco dos atletas antes do relaxamento variou de 136,13 a 140,73 da primeira semana para a oitava semana; após a introdução do treinamento de relaxamento, a frequência cardíaca dos atletas foi de 84,71, sendo a frequência cardíaca mínima registrada de 80,74. Pode-se observar que o treinamento de relaxamento permite aos atletas se recuperarem rapidamente para um estado normal e alcançarem o objetivo de relaxamento. Conclusão: Adicionar o programa de treinamento de relaxamento para aliviar a fadiga após o vôlei evidenciou-se útil para melhorar o desempenho dos jogadores de vôlei. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.
RESUMEN Introducción: El voleibol exige de los deportistas en entrenamiento continuo un fuerte compromiso y la utilización de técnicas de resistencia deportiva, siendo imprescindible su relajación después del entrenamiento. Objetivo: Este trabajo investiga si el entrenamiento de relajación después del voleibol es beneficioso en los niveles competitivos de los jugadores de voleibol. Métodos: 60 jugadoras de voleibol de entre 20 y 23 años fueron seleccionadas como participantes en el experimento. Recibieron entrenamiento de relajación durante 8 semanas y se registraron los cambios en la frecuencia cardiaca antes y después de la relajación. Resultados: La frecuencia cardíaca de los deportistas en estado de reposo antes del entrenamiento varió de 79,93 en la primera semana a 81,07 en la octava semana; tras la práctica del voleibol, la frecuencia cardíaca de los deportistas antes de la relajación varió de 136,13 a 140,73 desde la primera semana hasta la octava semana; tras la introducción del entrenamiento de relajación, la frecuencia cardíaca de los deportistas fue de 84,71, y la frecuencia cardíaca mínima registrada fue de 80,74. Se puede observar que el entrenamiento de relajación permite a los atletas recuperarse rápidamente a un estado normal y alcanzar el objetivo de la relajación. Conclusión: Añadir el programa de entrenamiento de relajación para aliviar la fatiga después del voleibol se mostró útil para mejorar el rendimiento de los jugadores de voleibol. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.
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@#Myeloid-derived suppressor cells (MDSCs) are a group of highly heterogeneous immunosuppressive cells produced in the bone marrow, which accumulate in large amounts under pathological conditions such as malignant tumors. MDSCs are the significant cell subsets that reduce patients' response to traditional treatment and promote tumor progression. In recent years, immune checkpoint blockade and adoptive transfusion of engineered T cells have significantly prolonged the survival of many patients with advanced malignant tumors, but the effective rate from 15% to 40% in some solid tumors including lung cancer, colorectal cancer etc., which is closely related to the immunosuppressive microenvironment in solid cancers. With the accumulation in tumor microenvironment, MDSCs reduce the anti-tumor immune response of patients by inhibiting T cell or NK cell proliferation and function, which is the key mechanism for patients tolerating to immunotherapy. Therefore, clarifying the accumulation and functional characteristics of MDSCs is an important research direction to explore the improvement of restoring immunotherapy. This article will systematically elaborate the regulatory mechanism of MDSC production, aggregation and immunosuppressive function, and outline the latest research progress of targeted MDSC therapy