RESUMEN
Adverse reactions to drug are extremely common and skin seems to be the most frequently affected target organ. There is no specific type of rash pathognomonic for drugs in general or one drug in particularcular. Any one drug may have the potential to cause a variety of reactions, which may develop at any time during the course of the drug intake. Even though cutaneous reactions to drugs are fairly common all over the world, yet there seems to be a much higher incidence of these reactions in this country. About 8-10% of the total inpatient admissions to local dermatology units are attributable to drugs directly or indirectly. Free availability and gross misuse of genuine and spurious drugs is a well-known problem, greatly appreciated by the profession. It is generally agreed that some effective steps ought to be taken in controlling the indiscriminate use of drugs in our society. Various types of cutaneous drug reactions including: Exanthematous and lichenoid drug reactions, urticaria, LE syndrome, Fixed drug eruption, drug induced alopecia and acne, Erythema multiform, Toxic epidermal necrolysis as well as vascular reaction, purpura and pigmentary changes are being discussed in the following text