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Objective To investigate the clinical efficacy of letrozole and clomiphene in the treatment of polycystic ovary syndrome in patients with ovulatory disorder. Methods Retrospective analysis of 480 cases diagnosed as polycystic ovary syndrome caused by ovarian infertility in patients with clinical diagnosis and treatment of information from January 2015 to January 2017, in which the treatment of cimetidine urinary hormone therapy as the control group (n=240), using letrozole urinary hormone therapy for the treatment group (n=240). The serum levels of sex hormones were measured before and after treatment in both groups. The endometrial thickness of patients was monitored by B-ultrasonography. Adverse reactions were recorded during treatment. Results The total effective rate was significantly higher in the treatment group than in the control group (P<0.05). The ovulation rate and pregnancy rate of the treatment group were 75.0% and 67.5% respectively, which was significantly higher than that of the control group (52.5%), 42.5% , χ2=(26.28, 30.30), P=(0.00,0.00). The levels of LH and T in the treatment group were (6.69±1.32) IU/L, (0.97±0.55) ng/mL, which was significantly lower than that in the control group (9.88±1.78) IU/L, (1.36±0.81) ng/mL. E2 in the treatment group was (44.25±10.71) pg/mL, significantly higher than that of the control group (39.35±7.69) pg/mL(P<0.05). The thickness of endometrium in the treatment group was significantly higher than that in the control group (P<0.05). No significant adverse reaction was observed during the treatment period. Conclusion Letrozole combined with urinary hormone treatment of polycystic ovary syndrome caused by ovarian disorder infertility patients with significant effect.
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Objective To investigate the clinical efficacy of letrozole and clomiphene in the treatment of polycystic ovary syndrome in patients with ovulatory disorder. Methods Retrospective analysis of 480 cases diagnosed as polycystic ovary syndrome caused by ovarian infertility in patients with clinical diagnosis and treatment of information from January 2015 to January 2017, in which the treatment of cimetidine urinary hormone therapy as the control group (n=240), using letrozole urinary hormone therapy for the treatment group (n=240). The serum levels of sex hormones were measured before and after treatment in both groups. The endometrial thickness of patients was monitored by B-ultrasonography. Adverse reactions were recorded during treatment. Results The total effective rate was significantly higher in the treatment group than in the control group (P<0.05). The ovulation rate and pregnancy rate of the treatment group were 75.0% and 67.5% respectively, which was significantly higher than that of the control group (52.5%), 42.5% , χ2=(26.28, 30.30), P=(0.00,0.00). The levels of LH and T in the treatment group were (6.69±1.32) IU/L, (0.97±0.55) ng/mL, which was significantly lower than that in the control group (9.88±1.78) IU/L, (1.36±0.81) ng/mL. E2 in the treatment group was (44.25±10.71) pg/mL, significantly higher than that of the control group (39.35±7.69) pg/mL(P<0.05). The thickness of endometrium in the treatment group was significantly higher than that in the control group (P<0.05). No significant adverse reaction was observed during the treatment period. Conclusion Letrozole combined with urinary hormone treatment of polycystic ovary syndrome caused by ovarian disorder infertility patients with significant effect.
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Objective Based on the radiographs to analyze the generic and the developing factors of hallux valgus.Methods Two hundred and forty-one cases were divided into two groups according to the symptoms suffered,which were normal group and hallux valgus group.All cases were female,aged 10 to 90 years old.The three parameters-the first intermetatarsal angle,sesamoid inclination angle and hallux valgus angle,were taken full weightbearing radiographs,analyzed by non-paired t test and Pearson correlation analysis according to age.Results In normal group,the first intermetatarsal angle was correlated with age ( correlation coefficient r =0.125,P =0.003 ).Sesamoid inclination angles in both groups were correlated with age( normal group r =0.384,P ＜0.001 ;hallux valgus group r =0.359,P =0.0002 ).However,hallux valgus angle had no correlation with age ( normal group r =0.066,hallux valgus group r=0.080).All 3 parameters in hallux valgus group were statistically larger than normal group.Conclusion Aging is a possible reason to cause the 1 st metatarsophlangeal joint deformity,but larger parameters were found in valgus group,suggesting the major cause of hallux valgus is congenital factor rather than aging.
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<p><b>OBJECTIVE</b>To study the effects of Yanshu injection on the combined treatment in the advanced primary liver cancer.</p><p><b>METHOD</b>Eighty-five cases of advanced primary liver cancer were treated with Yanshu injection combining with chemotherapy or only chemotherapy. The curative effects, pain genesic rate, one year survival rate, survival quality of life and cell immune functions were observed.</p><p><b>RESULT</b>The remission rate and one year survival rate of the trial group were 60.5% and 51.2%, respectively, and were significantly higher than those (45.2% and 40.5%) of the control group (P < 0.05). The pain relief rate of the trial group was significantly higher than that of the control group (P < 0.05). The improvement of the quality of life was higher than that of the contral group (P < 0.01). The ability of the T-cell subgroup and NK-cell of the trail group were significantly difference between pre-and post-treatment (P < 0.01 or 0.05); however, that of the control group was no obviously change.</p><p><b>CONCLUSION</b>Yanshu injection combination with chemotherapy can raise the curative effect, one year survival rate and cellular immune function, reduce pain genesic rate and toxicity of chemotherapy, and improve the quality of life of the patients with advanced primary liver cancer, which is worthy to be recommended for clinical application.</p>