RESUMEN
obesity is independently associated with increased oxidative stress in men and women. Natural antioxidants showed substantial antioxidative and anti-inflammatory activities in vivo. In this study, we examined the preventive effect of antioxidants supplement and/or restricted diet on the development of obesity induced by feeding a high-fat [HF] diet. The present study was conducted at Hamadan University of Medical Sciences in 2009. Forty-eight male Wistar rats were randomly assigned to HF purified diet [61% kcal from fat] ad libitum, HF restricted [30%], HF supplemented with astaxanthin, vitamin E and C [HFS], HFS restricted [30%] for 12 weeks. Daily food intake and weekly body weight gain were measured. The collected data were analyzed by the SPSS software using Colmogroph- Smirnov, One-Way ANOVA, and Two-Way ANOVA. Dietary antioxidants suppressed body weight gain in the HF-diet ad libitum [-9.8%], and in HF restricted diet [-18.14%]. Energy intake was not significant in HF with HFS [58.8 and 58.6 kcal/rat/d, respectively] and in HF restricted with HFS restricted [41.7 and 41.6 kcal/rat/d, respectively]. Results of this study suggest that antioxidants supplement might be of value in reducing the likelihood of obesity in rats fed with high-fat diets, especially when accompanying with restricted diets