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J. appl. oral sci ; 25(3): 243-249, May-June 2017. tab, graf
Artículo en Inglés | LILACS, BBO | ID: biblio-893622

RESUMEN

Abstract Objective Alendronate (ALN) inhibits osteoclastic bone resorption and triggers osteostimulative properties both in vivo and in vitro, as shown by increase in matrix formation. This study aimed to explore the efficacy of 1% ALN gel as local drug delivery (LDD) in adjunct to scaling and root planing (SRP) for the treatment of chronic periodontitis among smokers. Material and Methods 75 intrabony defects were treated in 46 male smokers either with 1% ALN gel or placebo gel. ALN gel was prepared by adding ALN into carbopol-distilled water mixture. Clinical parameters [modified sulcus bleeding index, plaque index, probing depth (PD), and periodontal attachment level (PAL)] were recorded at baseline, at 2 months, and at 6 months, while radiographic parameters were recorded at baseline and at 6 months. Defect fill at baseline and at 6 months was calculated on standardized radiographs by using the image analysis software. Results Mean PD reduction and mean PAL gain were found to be greater in the ALN group than in the placebo group, both at 2 and 6 months. Furthermore, a significantly greater mean percentage of bone fill was found in the ALN group (41.05±11.40%) compared to the placebo group (2.5±0.93%). Conclusions The results of this study showed 1% ALN stimulated a significant increase in PD reduction, PAL gain, and an improved bone fill compared to placebo gel in chronic periodontitis among smokers. Thus, 1% ALN, along with SRP, is effective in the treatment of chronic periodontitis in smokers.


Asunto(s)
Humanos , Masculino , Adulto , Persona de Mediana Edad , Fumar/efectos adversos , Raspado Dental/métodos , Alendronato/administración & dosificación , Conservadores de la Densidad Ósea/administración & dosificación , Periodontitis Crónica/etiología , Periodontitis Crónica/terapia , Osteoclastos/efectos de los fármacos , Factores de Tiempo , Radiografía , Fumar/fisiopatología , Índice Periodontal , Índice de Placa Dental , Reproducibilidad de los Resultados , Resultado del Tratamiento , Sistemas de Liberación de Medicamentos , Quimioterapia Adyuvante , Pérdida de la Inserción Periodontal , Estadísticas no Paramétricas , Periodontitis Crónica/fisiopatología , Periodontitis Crónica/diagnóstico por imagen , Geles
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